Defending against smallpox: a focus on vaccines

Emily A. Voigt, Richard B. Kennedy, Gregory A. Poland

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Smallpox has shaped human history, from the earliest human civilizations well into the 20th century. With high mortality rates, rapid transmission, and serious long-term effects on survivors, smallpox was a much-feared disease. The eradication of smallpox represents an unprecedented medical victory for the lasting benefit of human health and prosperity. Concerns remain, however, about the development and use of the smallpox virus as a biological weapon, which necessitates the need for continued vaccine development. Smallpox vaccine development is thus a much-reviewed topic of high interest. This review focuses on the current state of smallpox vaccines and their context in biodefense efforts.

Original languageEnglish (US)
Pages (from-to)1197-1211
Number of pages15
JournalExpert review of vaccines
Issue number9
StatePublished - Sep 1 2016


  • Smallpox
  • biological warfare
  • bioterrorism
  • smallpox vaccine
  • vaccinia virus

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery


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