TY - JOUR
T1 - Deep Learning Artificial Intelligence Model for Assessment of Hip Dislocation Risk Following Primary Total Hip Arthroplasty From Postoperative Radiographs
AU - Rouzrokh, Pouria
AU - Ramazanian, Taghi
AU - Wyles, Cody C.
AU - Philbrick, Kenneth A.
AU - Cai, Jason C.
AU - Taunton, Michael J.
AU - Maradit Kremers, Hilal
AU - Lewallen, David G.
AU - Erickson, Bradley J.
N1 - Funding Information:
Funding: This work was supported by the Mayo Foundation Presidential Fund and the National Institutes of Health (NIH) [grant numbers R01AR73147 and P30AR76312 ]. The funding source had no role in the study design; collection, analysis, and interpretation of the data; the writing of the report; or the decision to submit the article for publication.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/6
Y1 - 2021/6
N2 - Background: Dislocation is a common complication following total hip arthroplasty (THA), and accounts for a high percentage of subsequent revisions. The purpose of this study is to illustrate the potential of a convolutional neural network model to assess the risk of hip dislocation based on postoperative anteroposterior pelvis radiographs. Methods: We retrospectively evaluated radiographs for a cohort of 13,970 primary THAs with 374 dislocations over 5 years of follow-up. Overall, 1490 radiographs from dislocated and 91,094 from non-dislocated THAs were included in the analysis. A convolutional neural network object detection model (YOLO-V3) was trained to crop the images by centering on the femoral head. A ResNet18 classifier was trained to predict subsequent hip dislocation from the cropped imaging. The ResNet18 classifier was initialized with ImageNet weights and trained using FastAI (V1.0) running on PyTorch. The training was run for 15 epochs using 10-fold cross validation, data oversampling, and augmentation. Results: The hip dislocation classifier achieved the following mean performance (standard deviation): accuracy = 49.5 (4.1%), sensitivity = 89.0 (2.2%), specificity = 48.8 (4.2%), positive predictive value = 3.3 (0.3%), negative predictive value = 99.5 (0.1%), and area under the receiver operating characteristic curve = 76.7 (3.6%). Saliency maps demonstrated that the model placed the greatest emphasis on the femoral head and acetabular component. Conclusion: Existing prediction methods fail to identify patients at high risk of dislocation following THA. Our radiographic classifier model has high sensitivity and negative predictive value, and can be combined with clinical risk factor information for rapid assessment of risk for dislocation following THA. The model further suggests radiographic locations which may be important in understanding the etiology of prosthesis dislocation. Importantly, our model is an illustration of the potential of automated imaging artificial intelligence models in orthopedics. Level of Evidence: Level III.
AB - Background: Dislocation is a common complication following total hip arthroplasty (THA), and accounts for a high percentage of subsequent revisions. The purpose of this study is to illustrate the potential of a convolutional neural network model to assess the risk of hip dislocation based on postoperative anteroposterior pelvis radiographs. Methods: We retrospectively evaluated radiographs for a cohort of 13,970 primary THAs with 374 dislocations over 5 years of follow-up. Overall, 1490 radiographs from dislocated and 91,094 from non-dislocated THAs were included in the analysis. A convolutional neural network object detection model (YOLO-V3) was trained to crop the images by centering on the femoral head. A ResNet18 classifier was trained to predict subsequent hip dislocation from the cropped imaging. The ResNet18 classifier was initialized with ImageNet weights and trained using FastAI (V1.0) running on PyTorch. The training was run for 15 epochs using 10-fold cross validation, data oversampling, and augmentation. Results: The hip dislocation classifier achieved the following mean performance (standard deviation): accuracy = 49.5 (4.1%), sensitivity = 89.0 (2.2%), specificity = 48.8 (4.2%), positive predictive value = 3.3 (0.3%), negative predictive value = 99.5 (0.1%), and area under the receiver operating characteristic curve = 76.7 (3.6%). Saliency maps demonstrated that the model placed the greatest emphasis on the femoral head and acetabular component. Conclusion: Existing prediction methods fail to identify patients at high risk of dislocation following THA. Our radiographic classifier model has high sensitivity and negative predictive value, and can be combined with clinical risk factor information for rapid assessment of risk for dislocation following THA. The model further suggests radiographic locations which may be important in understanding the etiology of prosthesis dislocation. Importantly, our model is an illustration of the potential of automated imaging artificial intelligence models in orthopedics. Level of Evidence: Level III.
KW - artificial intelligence
KW - convolutional neural network
KW - deep learning
KW - dislocation
KW - total hip arthroplasty
KW - total hip replacement
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U2 - 10.1016/j.arth.2021.02.028
DO - 10.1016/j.arth.2021.02.028
M3 - Article
C2 - 33663890
AN - SCOPUS:85101884073
SN - 0883-5403
VL - 36
SP - 2197-2203.e3
JO - Journal of Arthroplasty
JF - Journal of Arthroplasty
IS - 6
ER -