Deep brain stimulation: Technology at the cutting edge

Rahul S. Shah, Su Youne Chang, Hoon Ki Min, Zang Hee Cho, Charles D. Blaha, Kendall H. Lee

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


Deep brain stimulation (DBS) surgery has been performed in over 75,000 people worldwide, and has been shown to be an effective treatment for Parkinson's disease, tremor, dystonia, epilepsy, depression, Tourette's syndrome, and obsessive compulsive disorder. We review current and em-erging evidence for the role of DBS in the management of a range of neurological and psychiatric conditions, and discuss the technical and practical aspects of performing DBS surgery. In the future, evolution of DBS technology may depend on several key areas, including better scientific understanding of its underlying mechanism of action, advances in high-spatial resolution imaging and development of novel electrophysiological and neurotransmitter microsensor systems. Such de-velopments could form the basis of an intelligent closed-loop DBS system with feedback-guided neuromodulation to optimize both electrode placement and therapeutic efficacy.

Original languageEnglish (US)
Pages (from-to)167-182
Number of pages16
JournalJournal of Clinical Neurology (Korea)
Issue number4
StatePublished - Dec 2010


  • Deep brain stimulation
  • Mechanism of action
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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