Deep brain stimulation for treatment-resistant depression: Efficacy, safety and mechanisms of action

Rodney J. Anderson, Mark A. Frye, Osama A. Abulseoud, Kendall H. Lee, Jane A. McGillivray, Michael Berk, Susannah J. Tye

Research output: Contribution to journalReview articlepeer-review

96 Scopus citations


Deep brain stimulation (DBS), a neuromodulation therapy that has been used successfully in the treatment of symptoms associated with movement disorders, has recently undergone clinical trials for individuals suffering from treatment-resistant depression (TRD). Although the small patient numbers and open label study design limit our ability to identify optimum targets and make definitive conclusions about treatment efficacy, a review of the published research demonstrates significant reductions in depressive symptomatology and high rates of remission in a severely treatment-resistant patient group. Despite these encouraging results, an incomplete understanding of the mechanisms of action underlying the therapeutic effects of DBS for TRD is highlighted, paralleling the incomplete understanding of the neuroanatomy of mood regulation and treatment resistance. Proposed mechanisms of action include short and long-term local effects of stimulation at the neuronal level, to modulation of neural network activity.

Original languageEnglish (US)
Pages (from-to)1920-1933
Number of pages14
JournalNeuroscience and Biobehavioral Reviews
Issue number8
StatePublished - Sep 2012


  • Deep brain stimulation
  • Inferior thalamic peduncle
  • Lateral habenula
  • Mood
  • Nucleus accumbens
  • Subgenual cingulate gyrus
  • Treatment resistant depression
  • Ventral capsule
  • Ventral striatum

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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