Decreased quality of life in children with hypothalamic hamartoma and treatment-resistant epilepsy

Cleo Park; Jennifer V. Wethe; John F. Kerrigan

doi:10.1177/0883073812439622

Decreased quality of life in children with hypothalamic hamartoma and treatment-resistant epilepsy

Cleo Park, Jennifer V. Wethe, John F. Kerrigan

Psychology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We evaluated health-related quality of life in patients with hypothalamic hamartoma, to see how it differs from that of children with more common neurologic disorders. We used the PedsQL 4.0, along with the Child Behavior Checklist, Hague Seizure Severity Scale, and Side Effects Scale, to evaluate presurgical patients with hypothalamic hamartoma and epilepsy (n = 21). The results were compared with those of age-matched cohorts with migraine (n = 19) and Benign Epilepsy with Central Temporal Spikes (n = 11). In comparison with the migraine group, the patients with hypothalamic hamartoma had decreased health-related quality of life across all domains of the PedsQL 4.0. Compared with the benign epilepsy group, the hypothalamic hamartoma cohort has a significantly lower score in School Function. Comorbid psychomotor retardation was predictive of lower quality of life. Research examining the efficacy of recently developed surgical treatments for hypothalamic hamartoma should include health-related quality of life as an outcome measure.

Original language	English (US)
Pages (from-to)	50-55
Number of pages	6
Journal	Journal of child neurology
Volume	28
Issue number	1
DOIs	https://doi.org/10.1177/0883073812439622
State	Published - Jan 2013

Keywords

PedsQL 4.0
epilepsy
hypothalamic hamartoma
migraine
quality of life
rolandic
seizure

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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10.1177/0883073812439622

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title = "Decreased quality of life in children with hypothalamic hamartoma and treatment-resistant epilepsy",

abstract = "We evaluated health-related quality of life in patients with hypothalamic hamartoma, to see how it differs from that of children with more common neurologic disorders. We used the PedsQL 4.0, along with the Child Behavior Checklist, Hague Seizure Severity Scale, and Side Effects Scale, to evaluate presurgical patients with hypothalamic hamartoma and epilepsy (n = 21). The results were compared with those of age-matched cohorts with migraine (n = 19) and Benign Epilepsy with Central Temporal Spikes (n = 11). In comparison with the migraine group, the patients with hypothalamic hamartoma had decreased health-related quality of life across all domains of the PedsQL 4.0. Compared with the benign epilepsy group, the hypothalamic hamartoma cohort has a significantly lower score in School Function. Comorbid psychomotor retardation was predictive of lower quality of life. Research examining the efficacy of recently developed surgical treatments for hypothalamic hamartoma should include health-related quality of life as an outcome measure.",

keywords = "PedsQL 4.0, epilepsy, hypothalamic hamartoma, migraine, quality of life, rolandic, seizure",

author = "Cleo Park and Wethe, {Jennifer V.} and Kerrigan, {John F.}",

note = "Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded entirely by the department of child neurology, Barrow Neurological Institute, St Joseph{\textquoteright}s Hospital and Medical Center in Phoenix, Arizona (prior to its merger with Phoenix Children{\textquoteright}s Hospital). The authors were employees of the institution and part of the Hypothalamic Hamartoma Program at the time. No special interest or commercial funding was obtained. Copyright: Copyright 2013 Elsevier B.V., All rights reserved.",

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Decreased quality of life in children with hypothalamic hamartoma and treatment-resistant epilepsy

Abstract

Keywords

ASJC Scopus subject areas

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