De novo hypertension after liver transplantation

S. C. Textor, G. F. DiBona, C. Thomas, A. Fitz, C. Pruchno, W. Lawton, J. A. Bertolatus, L. Tobacman

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone. The pathogenesis appears to be multifactorial but involves rapidly rising vasoconstrictor tone in renal and systemic vascular beds. Much of this tone reflects abnormal vascular function, characterized by impaired prostacyclin and EDRF effects, in conjunction with increased vasoconstriction due to endothelin and possibly other factors. Effective management of the transplant recipient depends on preventing excessive vasoconstriction, usually with calcium channel blocking agents.

Original languageEnglish (US)
Pages (from-to)257-267
Number of pages11
Issue number2
StatePublished - 1993


  • cyclosporine
  • endothelins
  • hypertension, posttransplant
  • kidney
  • liver transplantation
  • prostaglandins
  • renal circulation

ASJC Scopus subject areas

  • Internal Medicine


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