TY - JOUR
T1 - De Novo Colitis Associated With Rituximab in 21 Patients at a Tertiary Center
AU - Eckmann, Jason D.
AU - Chedid, Victor
AU - Quinn, Kevin P.
AU - Bonthu, Neelima
AU - Nehra, Vandana
AU - Raffals, Laura E.
N1 - Publisher Copyright:
© 2020 AGA Institute
PY - 2020/1
Y1 - 2020/1
N2 - Rituximab, a monoclonal antibody directed against the CD20 antigen on B lymphocytes, is commonly used in the treatment of hematologic malignancies and rheumatologic disorders.1,2 It acts to rapidly deplete the B lymphocyte population through multiple mechanisms, leading to dysregulation of the immune system.3 Rituximab has been associated with numerous adverse gastrointestinal effects including diarrhea and bowel perforation, and recent reports have associated rituximab with the development of de novo inflammatory bowel disease (IBD).4,5 To our knowledge, there have been no reports of microscopic colitis (MC) associated with rituximab therapy. We aimed to identify patients with rituximab-associated colitis, and to better characterize the clinical features and disease course of these patients.
AB - Rituximab, a monoclonal antibody directed against the CD20 antigen on B lymphocytes, is commonly used in the treatment of hematologic malignancies and rheumatologic disorders.1,2 It acts to rapidly deplete the B lymphocyte population through multiple mechanisms, leading to dysregulation of the immune system.3 Rituximab has been associated with numerous adverse gastrointestinal effects including diarrhea and bowel perforation, and recent reports have associated rituximab with the development of de novo inflammatory bowel disease (IBD).4,5 To our knowledge, there have been no reports of microscopic colitis (MC) associated with rituximab therapy. We aimed to identify patients with rituximab-associated colitis, and to better characterize the clinical features and disease course of these patients.
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U2 - 10.1016/j.cgh.2019.03.027
DO - 10.1016/j.cgh.2019.03.027
M3 - Short survey
C2 - 30905719
AN - SCOPUS:85076378096
SN - 1542-3565
VL - 18
SP - 252
EP - 253
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 1
ER -