TY - JOUR
T1 - Data Mining for Biomarker Development
T2 - A Review of Tissue Specificity Analysis
AU - Klee, Eric W.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/3
Y1 - 2008/3
N2 - Novel biomarker development requires a significant resource commitment to translate candidate markers into clinical assays. Consequently, it is imperative high quality candidates are selected early in a biomarker development program. High throughput gene expression data are routinely used to identify transcripts differentially expressed in diseased versus normal samples. Data-mining Expressed Sequence Tag, Serial Analysis of Gene Expression, Massively Parallel Signature Sequencing, and microarray expression databases can provide additional information on the expression of candidate biomarkers across multiple tissues, organs, and disease states. From this information, quantitative measures of tissue-specific gene specificity are computed and used to guide candidate biomarker selection.
AB - Novel biomarker development requires a significant resource commitment to translate candidate markers into clinical assays. Consequently, it is imperative high quality candidates are selected early in a biomarker development program. High throughput gene expression data are routinely used to identify transcripts differentially expressed in diseased versus normal samples. Data-mining Expressed Sequence Tag, Serial Analysis of Gene Expression, Massively Parallel Signature Sequencing, and microarray expression databases can provide additional information on the expression of candidate biomarkers across multiple tissues, organs, and disease states. From this information, quantitative measures of tissue-specific gene specificity are computed and used to guide candidate biomarker selection.
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U2 - 10.1016/j.cll.2007.10.009
DO - 10.1016/j.cll.2007.10.009
M3 - Review article
C2 - 18194723
AN - SCOPUS:37849011977
SN - 0272-2712
VL - 28
SP - 127
EP - 143
JO - Clinics in Laboratory Medicine
JF - Clinics in Laboratory Medicine
IS - 1
ER -