Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: Results from two independent cohorts

Hervé Ghesquières, Matthew J. Maurer, Olivier Casasnovas, Stephen M. Ansell, Beth R. Larrabee, Eva Lech-Maranda, Anne J. Novak, Anne Laure Borrel, Susan L. Slager, Pauline Brice, Cristine Allmer, Annie Brion, Steven C. Ziesmer, Franck Morschhauser, Thomas M. Habermann, Isabelle Gaillard, Brian K. Link, Aspasia Stamatoullas, Christophe Fermé, Ahmet DoganWilliam R. Macon, Josée Audouin, James R. Cerhan, Gilles Salles

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Background: Cytokines are important immune mediators of classical Hodgkin lymphoma (CHL) pathogenesis, and circulating levels at diagnosis may help predict prognosis. Germline single nucleotide polymorphisms (SNPs) in immune genes have been correlated with cytokine production and function. Methods: We investigated whether selected germline SNPs in IL10 (rs1800890, rs1800896, rs1800871, rs1800872), TNFA (rs1800629), IL6 (rs1800795), ILRN (rs419598), INFG (rs2430561) and CCL17 (rs223828) were associated with circulating levels of related cytokines at diagnosis and progression-free survival (PFS) in CHL. Patients were from France (GELA, N=. 464; median age. =. 32. years) and the United States (Iowa/Mayo Specialized Program Of Research Excellence [SPORE], N=. 239; median age. =. 38. years); 22% of 346 CHL cases with EBV tumor status were positive. Results: There was no association with any of the SNPs with cytokine levels. Overall, there was no association of any of the SNPs with PFS. In exploratory analyses by EBV status, TNFA rs1800629 (HRAA/AG=2.41; 95%CI, 1.17-4.94) was associated with PFS in EBV-negative GELA patients, with similar trends in the SPORE patients (HRAA/AG=1.63; 95%CI, 0.61-4.40). In a meta-analysis of the two studies, TNFA (HRAA/AG=2.11; 95%CI, 1.18-3.77; P=0.01) was statistically significant, and further adjustment for the international prognostic system did not alter this result. Conclusions: This study showed that germline variation in TNFA was associated with CHL prognosis for EBV-negative patients, which will require confirmation. These results support broader studies on the differential impact of genetic variation in immune genes on EBV-positive vs. EBV-negative CHL pathogenesis.

Original languageEnglish (US)
Pages (from-to)523-531
Number of pages9
Issue number2
StatePublished - Nov 2013


  • Cytokines
  • EBV
  • Hodgkin lymphoma
  • Polymorphism
  • TNFA

ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Biochemistry
  • Immunology and Allergy
  • Immunology


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