Cytogenetic studies of epithelial ovarian carcinoma

Robert B. Jenkins, Duane Bartelt, Paul Stalboerger, Diane Persons, Richard J. Dahl, Karl Podratz, Gary Keeney, Lynn Hartmann

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


We performed cytogenetic studies of 36 human epithelial ovarian carcinomas using in situ culture and robotic harvest. We obtained analyzable metaphases of all 36 tumors (100%). One or more chromosomally abnormal clones were observed in 80% of tumors. Common clonal chromosome gains (each occurring in six or more cases) included +1, +2, +3, +6, +7, +9, and +12. Common clonal chromosome losses (occurring in 12 or more cases) included -X, -4, -8, -11, -13, -15, -17, and -22. Common clonal structural abnormalities (occurring in four or more cases) involved regions 1p36, 1q32, 1q42, 3p13→p26, 3q26→q29, 7p22, 9q34, 11p13-p15, 17q1→q23, 19p13.3, and 19q13.3. Trisomy 12 was noted as the sole anomaly in three of five borderline and grade 1 tumors. Two grade 2 tumors contained i(1q), -14, -15 and -22. The results suggest that the pathogenesis of borderline and low-grade tumors may differ from that of higher grade tumors. Two high-grade tumors had an apparent translocation between 17q21 and 19p13.3, two chromosome regions believed to be critical to ovarian carcinogenesis.

Original languageEnglish (US)
Pages (from-to)76-86
Number of pages11
JournalCancer Genetics and Cytogenetics
Issue number1
StatePublished - Nov 1993

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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