TY - JOUR
T1 - Cytogenetic and molecular cytogenetic findings of intimal sarcoma
AU - Zhang, Hongying
AU - MacDonald, William D.
AU - Erickson-Johnson, Michele
AU - Wang, Xiaoke
AU - Jenkins, Robert B.
AU - Oliveira, Andre M.
N1 - Funding Information:
Editing, proofreading, and reference verification were provided by the Section of Scientific Publications, Mayo Clinic. This work was supported in part by funding from Fraternal Order of Eagles Foundation Award and research grant CR20 Grant Award Program 14546, Mayo Clinic.
PY - 2007/12
Y1 - 2007/12
N2 - Intimal sarcomas are exceptionally rare tumors that arise from the tunica intima of large vessels. Most intimal sarcomas are high-grade tumors that exhibit fibroblastic or myofibroblastic differentiation. We report the cytogenetic findings of a tumor from a 57-year-old man. The tumor had a pleomorphic and spindle-cell morphology, and it also exhibited a complex karyotype that was characterized by several numeric and structural chromosomal abnormalities. Molecular cytogenetic analysis showed amplification of MDM2, SAS, and CDK4, but not of HMGA2, ATF1, or DDIT3, which supported the findings of a previous comparative genomic hybridization study. Further studies are needed to determine whether the cytogenetic abnormalities found in this case are recurrent events for this poorly characterized malignancy.
AB - Intimal sarcomas are exceptionally rare tumors that arise from the tunica intima of large vessels. Most intimal sarcomas are high-grade tumors that exhibit fibroblastic or myofibroblastic differentiation. We report the cytogenetic findings of a tumor from a 57-year-old man. The tumor had a pleomorphic and spindle-cell morphology, and it also exhibited a complex karyotype that was characterized by several numeric and structural chromosomal abnormalities. Molecular cytogenetic analysis showed amplification of MDM2, SAS, and CDK4, but not of HMGA2, ATF1, or DDIT3, which supported the findings of a previous comparative genomic hybridization study. Further studies are needed to determine whether the cytogenetic abnormalities found in this case are recurrent events for this poorly characterized malignancy.
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U2 - 10.1016/j.cancergencyto.2007.08.013
DO - 10.1016/j.cancergencyto.2007.08.013
M3 - Article
C2 - 18036403
AN - SCOPUS:36148996842
SN - 0165-4608
VL - 179
SP - 146
EP - 149
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -