Cytogenetic abnormalities in MGUS and myeloma

Research output: Chapter in Book/Report/Conference proceedingChapter


There is clear evidence that chromosomal abnormalities play a major role in the pathogenesis and progression of multiple myeloma (MM). MM can be divided into two major subcategories: hyperdiploid MM (H-MM) which is composed of cases with multiple trisomies of the odd numbered chromosomes and non-hyperdiploid MM (NH-MM) which is characterized by translocations of the IgH locus. Specific cytogenetic abnormalities predict the clinical outcome of patients. Determination of the common cytogenetic aberrations is an integral part of MM patients' clinical evaluation.

Original languageEnglish (US)
Title of host publicationNeoplastic Diseases of the Blood
PublisherSpringer New York
Number of pages11
ISBN (Electronic)9781461437642
ISBN (Print)1461437636, 9781461437635
StatePublished - Nov 1 2013


  • Monoclonal gammopathy of undetermined significance cytogenetics
  • Multiple myeloma cytogenetics
  • Translocations

ASJC Scopus subject areas

  • Medicine(all)


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