TY - JOUR
T1 - Cystone® for 1 year did not change urine chemistry or decrease stone burden in cystine stone formers
AU - Erickson, Stephen B.
AU - Vrtiska, Terri J.
AU - Canzanello, Vincent J.
AU - Lieske, John C.
N1 - Funding Information:
Acknowledgments The authors wish to thank Beverly Tietje, study coordinator; and Kathy Laabs and Joni Langowski, secretaries, for their invaluable assistance in performing the study and preparing the manuscript, respectively. Funding of the research aspects of the study (2 of the 4 duplicate urine supersaturations, pregnancy testing, and statistical analysis and all Cystone® and placebo tablets) were provided by the Mayo Foundation and Himalaya Health Care. The entire design of the study, its supervision, data analysis, manuscript preparation and decision to publish were entirely the work of the authors. None of the authors have any Wnancial interest in Himalaya Health Care. Investigators on this study (J.C. Lieske, T.J. Vrtiska) were partially supported by the Mayo Clinic O’Brien Urology Research Center (P50 DK083007). Cystone® tablets and partial study funding were supplied by Himalaya Health Care.
PY - 2011/6
Y1 - 2011/6
N2 - Cystine kidney stones frequently recur because inadequate prevention exists. We recruited documented recurrent cystine kidney stone formers (6 men, 4 women, 44 ± 17 years) into a 2-phased study to assess safety and effectiveness of Cystone®, a herbal treatment used to prevent and facilitate passage of cystine kidney stones. The Wrst phase was a randomized double-blinded 12 weeks crossover study assessing the eVect of Cystone ® versus placebo (2 tablets BID) on urinary chemistries. The second phase was an open label 1 year study of Cystone® to determine if renal stone burden decreased, as assessed by quantitative and subjective assessment of CT. There was no statistically signiWcant change of urinary composition from baseline short (6 weeks) or long (52 weeks) term on Cystone®, including volume (2,525, 2,611, 2,730 ml), pH (6.7, 6.7, 7.05), and cystine excretion (2,770, 2,889, 4,025 μmol). Pre and post-CT was available in nine patients. Although seven kidneys lost stones spontaneously or surgically, overall stone burden increased in seven kidneys, was unchanged in nine, and fell in only two. Quantitative scoring increased in both the left and right kidneys (1,602-1667 and 301-2,064 volumetric units, respectively). Therefore, this study does not suggest that Cystone ® has a favorable eVect on urinary chemistries that could decrease cystine stone formation, nor does it appear to prevent stone growth or promote stone passage over a 1-year period.
AB - Cystine kidney stones frequently recur because inadequate prevention exists. We recruited documented recurrent cystine kidney stone formers (6 men, 4 women, 44 ± 17 years) into a 2-phased study to assess safety and effectiveness of Cystone®, a herbal treatment used to prevent and facilitate passage of cystine kidney stones. The Wrst phase was a randomized double-blinded 12 weeks crossover study assessing the eVect of Cystone ® versus placebo (2 tablets BID) on urinary chemistries. The second phase was an open label 1 year study of Cystone® to determine if renal stone burden decreased, as assessed by quantitative and subjective assessment of CT. There was no statistically signiWcant change of urinary composition from baseline short (6 weeks) or long (52 weeks) term on Cystone®, including volume (2,525, 2,611, 2,730 ml), pH (6.7, 6.7, 7.05), and cystine excretion (2,770, 2,889, 4,025 μmol). Pre and post-CT was available in nine patients. Although seven kidneys lost stones spontaneously or surgically, overall stone burden increased in seven kidneys, was unchanged in nine, and fell in only two. Quantitative scoring increased in both the left and right kidneys (1,602-1667 and 301-2,064 volumetric units, respectively). Therefore, this study does not suggest that Cystone ® has a favorable eVect on urinary chemistries that could decrease cystine stone formation, nor does it appear to prevent stone growth or promote stone passage over a 1-year period.
KW - Computerized tomography
KW - Cystone
KW - Herb
KW - Kidney calculi
KW - Nephrolithiasis
KW - Quantitative CT
KW - Supersaturation
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U2 - 10.1007/s00240-010-0334-x
DO - 10.1007/s00240-010-0334-x
M3 - Article
C2 - 21161651
AN - SCOPUS:80051673332
SN - 0300-5623
VL - 39
SP - 197
EP - 203
JO - Urological Research
JF - Urological Research
IS - 3
ER -