Cystone® for 1 year did not change urine chemistry or decrease stone burden in cystine stone formers

Stephen B. Erickson, Terri J. Vrtiska, Vincent J. Canzanello, John C. Lieske

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Cystine kidney stones frequently recur because inadequate prevention exists. We recruited documented recurrent cystine kidney stone formers (6 men, 4 women, 44 ± 17 years) into a 2-phased study to assess safety and effectiveness of Cystone®, a herbal treatment used to prevent and facilitate passage of cystine kidney stones. The Wrst phase was a randomized double-blinded 12 weeks crossover study assessing the eVect of Cystone ® versus placebo (2 tablets BID) on urinary chemistries. The second phase was an open label 1 year study of Cystone® to determine if renal stone burden decreased, as assessed by quantitative and subjective assessment of CT. There was no statistically signiWcant change of urinary composition from baseline short (6 weeks) or long (52 weeks) term on Cystone®, including volume (2,525, 2,611, 2,730 ml), pH (6.7, 6.7, 7.05), and cystine excretion (2,770, 2,889, 4,025 μmol). Pre and post-CT was available in nine patients. Although seven kidneys lost stones spontaneously or surgically, overall stone burden increased in seven kidneys, was unchanged in nine, and fell in only two. Quantitative scoring increased in both the left and right kidneys (1,602-1667 and 301-2,064 volumetric units, respectively). Therefore, this study does not suggest that Cystone ® has a favorable eVect on urinary chemistries that could decrease cystine stone formation, nor does it appear to prevent stone growth or promote stone passage over a 1-year period.

Original languageEnglish (US)
Pages (from-to)197-203
Number of pages7
JournalUrological Research
Issue number3
StatePublished - Jun 2011


  • Computerized tomography
  • Cystone
  • Herb
  • Kidney calculi
  • Nephrolithiasis
  • Quantitative CT
  • Supersaturation

ASJC Scopus subject areas

  • Urology


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