Cyclosporine in Primary Biliary Cirrhosis

Santiago J. Munoz, Russell H. Wiesner, Jurgen Ludwig, Keith D. Lindor, Roberta A. Jorgensen, William P. Baldus, Henry A. Homburger, E. Rolland Dickson

Research output: Contribution to journalLetterpeer-review

1 Scopus citations


To the Editor: Wiesner et al. are to be congratulated for their innovative study on the use of cyclosporine in early primary biliary cirrhosis (May 17 issue).* However, it is important to point out that although the authors claim that this was a double-blind protocol, the study was not rigorously blinded. Even at low dosages, cyclosporine leads to a significant and noticeable elevation in the arterial blood pressure and serum creatinine level. Hypertrichosis, tremors, and gum hyperplasia also develop in many patients. These features are readily perceived by the patients themselves. In the study by Wiesner et al., 15 of…

Original languageEnglish (US)
Pages (from-to)1352
Number of pages1
JournalNew England Journal of Medicine
Issue number19
StatePublished - Nov 8 1990

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Cyclosporine in Primary Biliary Cirrhosis'. Together they form a unique fingerprint.

Cite this