Abstract
Cutaneous B-cell pseudolymphoma (CBPL), or cutaneous lymphoid hyperplasia, is the most common pseudolymphoma. It typically responds well to local treatment and follows a benign course. Herein, we describe the unique case of a patient with CBPL that was refractory to a variety of treatments, with subsequent response to rituximab followed by methotrexate. This case explores the complex interplay of T and B lymphocytes, and the potential role of perifollicular T cells in treatment resistant CBPL Further, it describes the additive therapeutic effect of rituximab and methotrexate to target both B cell and T cell populations in CBPL, a strategy already employed in a number of other conditions.
Original language | English (US) |
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Article number | 8 |
Journal | Dermatology Online Journal |
Volume | 27 |
Issue number | 9 |
DOIs | |
State | Published - 2021 |
Keywords
- B-cell disorders
- Methotrexate
- Pseudolymphoma
- Rituximab
ASJC Scopus subject areas
- Dermatology