Cushing's case XLV: Minnie G.

Giuseppe Lanzino, Niki F. Maartens, Edward R. Laws

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


A 23-year-old patient who was examined in 1910 by Harvey Cushing triggered his lifelong interest in the syndrome that bears his name. "Minnie G.," as she became historically known, presented with a ". . . syndrome of painful obesity, hypertrichosis, and amenorrhea with overdevelopment of secondary sexual characteristics accompanying a low grade of hydrocephalus and increased cerebral tension." This case stimulated Harvey Cushing's inquisitive mind and sparked an interest that 20 years later culminated in his seminal report, "The basophil adenomas of the pituitary gland and their clinical manifestations (pituitary basophilism)." In this classic work, Cushing reported in detail the cases of two patients encountered from his own practice and 10 similar cases collected from the literature. Minnie G. was the first case that Cushing reported. The clinical course of that case is briefly reviewed in this article.

Original languageEnglish (US)
Pages (from-to)231-234
Number of pages4
JournalJournal of neurosurgery
Issue number1
StatePublished - 2002


  • Cushing syndrome
  • Harvey Cushing
  • Neurosurgical history
  • Pituitary adenoma
  • Primary pigmented nodular adrenal disease

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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