Current status of adjuvant endocrine therapy for breast cancer

James N. Ingle

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Adjuvant endocrine therapy is a vitally important modality for treatment of women with resected hormone-sensitive breast cancer as indicated by the presence of estrogen and/or progesterone receptors in the tumor. It is not recommended in those patients whose tumors lack these hormone receptors. Tamoxifen for 5 years has been shown to reduce the risk of recurrence and death irrespective of menopausal status or use of adjuvant chemotherapy. In postmenopausal women, the major research emphasis relates to the use of third-generation aromatase inhibitors in sequence with, instead of, and in combination with tamoxifen. In premenopausal women, ovarian ablation/suppression has demonstrated efficacy comparable with some chemotherapy regimens, but its role in women receiving chemotherapy remains to be determined.

Original languageEnglish (US)
Pages (from-to)4392s-4396s
JournalClinical Cancer Research
StatePublished - 2001

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Current status of adjuvant endocrine therapy for breast cancer'. Together they form a unique fingerprint.

Cite this