Questões atuais relativas à dosagem e à descrição da excreção urinária de albumina

Translated title of the contribution: Current issues in measurement and report of urinary albumin excretion

W. Greg Miller, David E. Bruns, Glen L. Hortin, Sverre Sandberg, Kristin M. Aakre, Matthew J. McQueen, Yoshihisa Itoh, John C. Lieske, David W. Seccombe, Graham Jones, David M. Bunk, Gary C. Curhan, Andrew S. Narva

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Urinary excretion of albumin indicates kidney damage and is recognized as a risk factor for progression of kidney disease and cardiovascular disease. The role of urinary albumin measurements has focused attention on the clinical need for accurate and clearly reported results. The National Kidney Disease Education Program and the IFCC convened a conference to assess the current state of preanalytical, analytical, and postanalytical issues affecting urine albumin measurements and to identify areas needing improvement. Content: The chemistry of albumin in urine is incompletely understood. Current guidelines recommend the use of the albumin/creatinine ratio (ACR) as a surrogate for the error-prone collection of timed urine samples. Although ACR results are affected by patient preparation and time of day of sample collection, neither is standardized. Considerable intermethod differences have been reported for both albumin and creatinine measurement, but trueness is unknown because there are no reference measurement procedures for albumin and no reference materials for either analyte in urine. The recommended reference intervals for the ACR do not take into account the large intergroup differences in creatinine excretion (e.g., related to differences in age, sex, and ethnicity) nor the continuous increase in risk related to albumin excretion. Discussion: Clinical needs have been identified for standardization of (a) urine collection methods, (b) urine albumin and creatinine measurements based on a complete reference system, (c) reporting of test results, and (d) reference intervals for the ACR.

Translated title of the contributionCurrent issues in measurement and report of urinary albumin excretion
Original languagePortuguese
Pages (from-to)187-206
Number of pages20
JournalJornal Brasileiro de Patologia e Medicina Laboratorial
Issue number3
StatePublished - Jun 2010

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology
  • Clinical Biochemistry


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