Current controversies in Crohn's disease: A roundtable discussion of the BRIDGe group

Miles P. Sparrow, Peter M. Irving, Leonard Baidoo, Brian Bressler, Adam S. Cheifetz, Shane M. Devlin, Laura E. Harrell, Jennifer Jones, Patricia L. Kozuch, Gil Y. Melmed, Fernando S. Velayos, Corey A. Siegel

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


In March 2008, a roundtable discussion was convened by the inflammatory bowel disease (IBD) specialist panel the BRIDGe (Building Resources and Research in IBD Globally) group, which consists of junior faculty gastroenterologists who have undergone advanced fellowship training at IBD referral centers in the United States, Canada, the United Kingdom, and Australia. An agenda was formulated to discuss three current controversies in Crohn's disease management: the role of 5-aminosalicylates, the use of biologic combination therapy versus monotherapy, and the use of step-up therapy versus top-down therapy for Crohn's disease. The aim of the meeting was three-fold: to review the data pertaining to each topic; to collect opinions from the participants as to their analysis of the literature and their current practice; and, where possible, to formulate recommendations of current best practice given the available evidence. This manuscript summarizes the discussions on these three areas of controversy in the current management of Crohn's disease.

Original languageEnglish (US)
Pages (from-to)713-720
Number of pages8
JournalGastroenterology and Hepatology
Issue number10
StatePublished - Oct 2008


  • 5-aminosalicylates
  • Biologic therapies
  • Crohn's disease
  • Immunomodulators
  • Inflammatory bowel disease

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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