Current Challenges in Vaccinology

Richard B. Kennedy, Inna G. Ovsyannikova, Peter Palese, Gregory A. Poland

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


The development of vaccines, which prime the immune system to respond to future infections, has led to global declines in morbidity and mortality from dreadful infectious communicable diseases. However, many pathogens of public health importance are highly complex and/or rapidly evolving, posing unique challenges to vaccine development. Several of these challenges include an incomplete understanding of how immunity develops, host and pathogen genetic variability, and an increased societal skepticism regarding vaccine safety. In particular, new high-dimensional omics technologies, aided by bioinformatics, are driving new vaccine development (vaccinomics). Informed by recent insights into pathogen biology, host genetic diversity, and immunology, the increasing use of genomic approaches is leading to new models and understanding of host immune system responses that may provide solutions in the rapid development of novel vaccine candidates.

Original languageEnglish (US)
Article number1181
JournalFrontiers in immunology
StatePublished - Jun 25 2020


  • genetics
  • genomics
  • transcriptomics
  • vaccine
  • vaccine development

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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