ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal–Anal Task Forces whitepaper

Arvind Dasari, Van K. Morris, Carmen J. Allegra, Chloe Atreya, Al B. Benson, Patrick Boland, Ki Chung, Mehmet S. Copur, Ryan B. Corcoran, Dustin A. Deming, Andrea Dwyer, Maximilian Diehn, Cathy Eng, Thomas J. George, Marc J. Gollub, Rachel A. Goodwin, Stanley R. Hamilton, Jaclyn F. Hechtman, Howard Hochster, Theodore S. HongFederico Innocenti, Atif Iqbal, Samuel A. Jacobs, Hagen F. Kennecke, James J. Lee, Christopher H. Lieu, Heinz Josef Lenz, O. Wolf Lindwasser, Clara Montagut, Bruno Odisio, Fang Shu Ou, Laura Porter, Kanwal Raghav, Deborah Schrag, Aaron J. Scott, Qian Shi, John H. Strickler, Alan Venook, Rona Yaeger, Greg Yothers, Y. Nancy You, Jason A. Zell, Scott Kopetz

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


An increasing number of studies are describing potential uses of circulating tumour DNA (ctDNA) in the care of patients with colorectal cancer. Owing to this rapidly developing area of research, the Colon and Rectal–Anal Task Forces of the United States National Cancer Institute convened a panel of multidisciplinary experts to summarize current data on the utility of ctDNA in the management of colorectal cancer and to provide guidance in promoting the efficient development and integration of this technology into clinical care. The panel focused on four key areas in which ctDNA has the potential to change clinical practice, including the detection of minimal residual disease, the management of patients with rectal cancer, monitoring responses to therapy, and tracking clonal dynamics in response to targeted therapies and other systemic treatments. The panel also provides general guidelines with relevance for ctDNA-related research efforts, irrespective of indication.

Original languageEnglish (US)
Pages (from-to)757-770
Number of pages14
JournalNature Reviews Clinical Oncology
Issue number12
StatePublished - Dec 2020

ASJC Scopus subject areas

  • Oncology


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