TY - JOUR
T1 - Critical limb ischemia
T2 - An update for interventional radiologists
AU - Brazeau, Nicholas F.
AU - Pinto, Erique G.
AU - Harvey, Harlan B.
AU - Oliveira, George R.
AU - Pomerantz, Benjamin J.
AU - Wicky, Stephan
AU - Oklu, Rahmi
N1 - Funding Information:
This work was supported by the Wellcome Trust (grant number 095778) and the Royal Society (grant number IC160132). R. E. S. is supported by a PhD fellowship awarded under the DELTAS Africa Initiative (grant number 107743); the Developing Excellence in Leadership, Training and Science Africa Initiative is an independent funding scheme of the African Academy of Sciences, Alliance for Accelerating Excellence in Science in Africa, and supported by the New Partnership for Africa's Development Planning and Coordinating Agency with funding from the Wellcome Trust (grant number 107743) and the UK government. The work was conducted at the Medical Research Council (MRC)/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, which is jointly funded by the UK MRC and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement and is also part of the EDCTP2 program supported by the European Union. Acknowledgments. The authors thank the Koome subcounty community members, their local council leaders and beach management committee members, and village health team members for participating in this study; the Koome Health Centre III for support; and the leadership of Mukono District, particularly the district health officer (Elly Tumushabe) and the councillor for Koome subcounty (Asuman Muwumuza), who are members of the Trial Steering Committee (TSC), for their support. The authors also thank the other members of the TSC: Heiner Grosskurth (chair), Edridah Tukahebwa, Narcis Kabatereine, Neil Pearce, Anatoli Kamali, and Monica Kuteesa; the Calvary Chapel Island Mission for providing voluntary counseling and human immunodeficiency virus (HIV) testing for community members, including study participants, in collaboration with our research program; and Moffat Nyirenda, Stephen Cose, and Ponsiano Ocama, who are members of R. E. S.'s doctoral committee, for their guidance and support. The Lake Victoria Island Intervention Study on Worms and Allergy-Related Diseases (LaVIISWA) trial team. Project leaders and physicians: Richard Sanya, Margaret Nampijja, Harriet Mpairwe, Barbara Nerima; statisticians and data managers: Emily Webb, Lawrence Lubyayi, Hellen Akurut, Justin Okello, Sebastian Owilla, Jacob Ochola; clinical officers: Christopher Zziwa, Milly Namutebi; nurses: Esther Nakazibwe, Josephine Tumusiime, Caroline Ninsiima, Susan Amongi, Grace Kamukama, Susan Iwala, Rita Asherwin, Rehema Nampijja, Florence Akello; internal monitor: Mirriam Akello; field workers: Robert Kizindo, Moses Sewankambo, Denis Nsubuga; laboratory staff and collaborators: Stephen Cose, Prossy Kabuubi Nakawungu, Emmanuel Niwagaba, Gloria Oduru, Grace Kabami, Elson Abayo, Fred Muwonge Kakooza, Joyce Kabagenyi, Gyaviira Nkurunungi, Angela Nalwoga, John Vianney Tushabe, Jacent Nassuuna, Bridgious Walusimbi; Boatman: David Abiriga; Driver: Richard Walusimbi; HIV counseling and testing: Cynthia Kabonesa; vector control program staff: James Kaweesa, Edridah Tukahebwa; administrative management: Moses Kizza; principal investigator: Alison Elliott.
PY - 2013
Y1 - 2013
N2 - Critical limb ischemia (CLI) is a growing epidemic with bleak patient outcomes. A variety of treatment modalities have been adopted to address CLI based on comorbidities, life expectancy, and the nature of the arterial disease. With advances in technology and treatment strategies, the clinical outcomes of CLI patients have significantly improved over recent years. However, despite progress, patency rates of both surgical and endovascular interventions, limb-salvage and amputation rates are still dismal. We review the epidemiology, treatment strategies, imaging modalities, and the microcirculation aspect of CLI.
AB - Critical limb ischemia (CLI) is a growing epidemic with bleak patient outcomes. A variety of treatment modalities have been adopted to address CLI based on comorbidities, life expectancy, and the nature of the arterial disease. With advances in technology and treatment strategies, the clinical outcomes of CLI patients have significantly improved over recent years. However, despite progress, patency rates of both surgical and endovascular interventions, limb-salvage and amputation rates are still dismal. We review the epidemiology, treatment strategies, imaging modalities, and the microcirculation aspect of CLI.
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U2 - 10.4261/1305-3825.DIR.5955-12.1
DO - 10.4261/1305-3825.DIR.5955-12.1
M3 - Review article
C2 - 23233402
AN - SCOPUS:84874606024
SN - 1305-3825
VL - 19
SP - 173
EP - 180
JO - Diagnostic and Interventional Radiology
JF - Diagnostic and Interventional Radiology
IS - 2
ER -