Critical cerebral perfusion pressure during tepid heart operations in dogs

Walter Plöchl, David J. Cook, Thomas A. Orszulak, Richard C. Daly

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Background. The management of blood pressure during cardiopulmonary bypass varies widely. This may be particularly relevant with the trend to warmer bypass temperatures and an older patient population. Therefore, we examined the minimal perfusion pressure that maintains cerebral oxygen delivery during cardiopulmonary bypass at 33°C. Methods. Ten dogs were placed on bypass anti body temperature was reduced to 33°C (α-stat pH management). At six randomly ordered mean arterial blood pressures (35, 40, 45, 50, 60, and 70 mm Hg), cerebral blood flow, oxygen delivery, and metabolic rate were determined. Results. Cerebral oxygen delivery was stable if the mean arterial pressure was greater than or equal to 60 mm Hg. If mean arterial pressure was less than or equal to 50 mm Hg, cerebral oxygen delivery decreased, and at less than 45 mm Hg cerebral ischemia was seen. Conclusions. In a dog without vascular disease, the brain becomes perfusion pressure-dependent at a mean arterial pressure of approximately 50 mm Hg. There is no leftward shift of the cerebral autoregulatory curve during bypass at 33°C. Greater support of mean arterial pressure during 'tepid' cardiopulmonary bypass is indicated in the current adult surgical population that is older and has vascular comorbidity.

Original languageEnglish (US)
Pages (from-to)118-123
Number of pages6
JournalAnnals of Thoracic Surgery
Issue number1
StatePublished - Jul 1998

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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