Abstract
This report describes a new human B7-like gene designated B7-H2. Cell surface expression of B7-H2 protein is detected in monocyte-derived immature dendritic cells. Soluble B7-H2 and immunoglobulin (Ig) fusion protein, B7-H2Ig, binds activated but not resting T cells and the binding is abrogated by inducible costimulator Ig (ICOSIg), but not CTLA4Ig. In addition, ICOSIg stains Chinese hamster ovary cells transfected with B7-H2 gene. By suboptimal cross-linking of CD3, costimulation of T-cell proliferation by B7-H2Ig is dose-dependent and correlates with secretion of interleukin (IL)-2, whereas optimal CD3 ligation preferentially stimulates IL-10 production. The results indicate that B7-H2 is a putative ligand for the ICOS T-cell molecule. (C) 2000 by The American Society of Hematology.
Original language | English (US) |
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Pages (from-to) | 2808-2813 |
Number of pages | 6 |
Journal | Blood |
Volume | 96 |
Issue number | 8 |
DOIs | |
State | Published - Oct 15 2000 |
ASJC Scopus subject areas
- Biochemistry
- Immunology
- Hematology
- Cell Biology