TY - JOUR
T1 - Cost-effectiveness projections of oxaliplatin and infusional fluorouracil versus irinotecan and bolus fluorouracil in first-line therapy for metastatic colorectal carcinoma
AU - Hillner, Bruce E.
AU - Schrag, Deborah
AU - Sargent, Daniel J.
AU - Fuchs, Charles S.
AU - Goldberg, Richard M.
PY - 2005/10/26
Y1 - 2005/10/26
N2 - BACKGROUND. The results of a randomized comparison study (N9741) showed that oxaliplatin and infusional fluorouracil (FU) (FOLFOX) was superior to the previous standard of care in the United States, irinotecan and bolus FU (IFL), as first-line therapy for patients with metastatic colon carcinoma. The trade-offs between costs and survival for these two regimens have not been explored. METHODS. A post-hoc, incremental cost-effectiveness (ICE) projection using simulated cohorts of patients starting FOLFOX or IFL was tracked for major clinical events, toxicities, and survival. Recurrence and survival risks were based on clinical trial data. Resource use was projected using observed dose intensity, duration of therapy, delays in therapy, and toxicities Grade > 2 in N9741. The frequency, costs, and consequences of second-line therapy were examined. The time frame was 5 years, and the perspective was that of Medicare as a third-party payer. RESULTS. Initial treatment with FOLFOX versus IFL had an average incremental cost of $29,523, a survival benefit of 4.4 months, and an ICE of $80,410 per life year (LY), $111,890 per quality-adjusted LY, and $89,080 per progression-free year. By using the 95% confidence interval for the time to progression observed in N9741, the ICE associated with FOLFOX ranged from $121,220 to $59,250 per LY. In the clinical trial, dose delays and skipped doses were frequent. If progression-free patients were treated without delay for the first year or lifetime, then the ICE for FOLFOX increased to $117,910 and $222,200 per LY, respectively. The ICE increased to $84,780 per LY when the model incorporated a revised IFL schedule with lower early toxicity and similar rates of treatment with second-line regimens. CONCLUSIONS. FOLFOX provided substantial benefits that incurred substantial additional costs. The ICE for FOLFOX fell into the upper range of commonly accepted oncology interventions in the context of the United States healthcare system.
AB - BACKGROUND. The results of a randomized comparison study (N9741) showed that oxaliplatin and infusional fluorouracil (FU) (FOLFOX) was superior to the previous standard of care in the United States, irinotecan and bolus FU (IFL), as first-line therapy for patients with metastatic colon carcinoma. The trade-offs between costs and survival for these two regimens have not been explored. METHODS. A post-hoc, incremental cost-effectiveness (ICE) projection using simulated cohorts of patients starting FOLFOX or IFL was tracked for major clinical events, toxicities, and survival. Recurrence and survival risks were based on clinical trial data. Resource use was projected using observed dose intensity, duration of therapy, delays in therapy, and toxicities Grade > 2 in N9741. The frequency, costs, and consequences of second-line therapy were examined. The time frame was 5 years, and the perspective was that of Medicare as a third-party payer. RESULTS. Initial treatment with FOLFOX versus IFL had an average incremental cost of $29,523, a survival benefit of 4.4 months, and an ICE of $80,410 per life year (LY), $111,890 per quality-adjusted LY, and $89,080 per progression-free year. By using the 95% confidence interval for the time to progression observed in N9741, the ICE associated with FOLFOX ranged from $121,220 to $59,250 per LY. In the clinical trial, dose delays and skipped doses were frequent. If progression-free patients were treated without delay for the first year or lifetime, then the ICE for FOLFOX increased to $117,910 and $222,200 per LY, respectively. The ICE increased to $84,780 per LY when the model incorporated a revised IFL schedule with lower early toxicity and similar rates of treatment with second-line regimens. CONCLUSIONS. FOLFOX provided substantial benefits that incurred substantial additional costs. The ICE for FOLFOX fell into the upper range of commonly accepted oncology interventions in the context of the United States healthcare system.
KW - Colorectal neoplasm
KW - Cost and cost analysis
KW - Cost-benefit analysis
KW - Decision modeling
KW - Irinotecan
KW - Metastatic disease
KW - Oxaliplatin
KW - Survival analysis
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U2 - 10.1002/cncr.21411
DO - 10.1002/cncr.21411
M3 - Article
C2 - 16177989
AN - SCOPUS:27244434988
SN - 0008-543X
VL - 104
SP - 1871
EP - 1884
JO - Cancer
JF - Cancer
IS - 9
ER -