This experimented tested the hypothesis that corticotropin-releasing factor (CRF) contributes to hippocampal ischemic injury. The antagonist to CRF (α-CRF) was administered intraventriculary 15 min prior to 10 min of transient forebrain ischemia in the Wistar rat. α-CRF demontrated a neuroprotective effect in a dose-dependent manner most notable in CA1. There was also an increase in postischemic EEG recovery. It is postulated that CRF contributes to hippocampal ischemic injury through increased neuronal activity.
- Corticotropin-releasing factor
ASJC Scopus subject areas
- Molecular Biology
- Clinical Neurology
- Developmental Biology