Corticobasal degeneration

Gerard M. Saranza, Jennifer L. Whitwell, Gabor G. Kovacs, Anthony E. Lang

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Corticobasal degeneration (CBD) is a rare neurodegenerative disease characterized by the predominance of pathological 4 repeat tau deposition in various cell types and anatomical regions. Corticobasal syndrome (CBS) is one of the clinical phenotypes associated with CBD pathology, manifesting as a progressive asymmetric akinetic-rigid, poorly levodopa-responsive parkinsonism, with cerebral cortical dysfunction. CBD can manifest as several clinical phenotypes, and similarly, CBS can also have a pathologic diagnosis other than CBD. This chapter discusses the clinical manifestations of pathologically confirmed CBD cases, the current diagnostic criteria, as well as the pathologic and neuroimaging findings of CBD/CBS. At present, therapeutic options for CBD remain symptomatic. Further research is needed to improve the clinical diagnosis of CBD, as well as studies on disease-modifying therapies for this relentlessly progressive neurodegenerative disorder.

Original languageEnglish (US)
Title of host publicationParkinsonism Beyond Parkinson's Disease
EditorsMaria Stamelou, Günter U. Höglinger
PublisherAcademic Press Inc
Number of pages50
ISBN (Print)9780128177303
StatePublished - 2019

Publication series

NameInternational Review of Neurobiology
ISSN (Print)0074-7742
ISSN (Electronic)2162-5514


  • 4R-tauopathy
  • Atypical parkinsonism
  • Corticobasal degeneration
  • Corticobasal syndrome
  • Tauopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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