Cortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging

Mary M. Machulda, Emily S. Lundt, Sabrina M. Albertson, Anthony J. Spychalla, Christopher G. Schwarz, Michelle M. Mielke, Clifford R. Jack, Walter K. Kremers, Prashanthi Vemuri, David S. Knopman, David T. Jones, Mark W. Bondi, Ronald C. Petersen

Research output: Contribution to journalArticlepeer-review


Introduction: We examined differences in cortical thickness in empirically derived mild cognitive impairment (MCI) subtypes in the Mayo Clinic Study of Aging. Methods: We compared cortical thickness of four incident MCI subtypes (n = 192) to 1257 cognitive unimpaired individuals. Results: The subtle cognitive impairment cluster had atrophy in the entorhinal and parahippocampal cortex. The amnestic, dysnomic, and dysexecutive clusters also demonstrated entorhinal cortex atrophy as well as thinning in temporal, parietal, and frontal isocortex in somewhat different patterns. Discussion: We found patterns of atrophy in each of the incident MCI clusters that corresponded to their patterns of cognitive impairment. The identification of MCI subtypes based on cognitive and structural features may allow for more efficient trial and study designs. Given individuals in the subtle cognitive impairment cluster have less structural changes and cognitive decline and may represent the earliest group, this could be a unique group to target with early interventions.

Original languageEnglish (US)
Pages (from-to)1013-1022
Number of pages10
JournalAlzheimer's and Dementia
Issue number7
StatePublished - Jul 1 2020


  • cluster analysis
  • cortical thickness
  • mild cognitive impairment
  • neuropsychology

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


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