TY - JOUR
T1 - Cortical and thalamic electrode implant followed by temporary continuous subthreshold stimulation yields long-term seizure freedom
T2 - A case report
AU - Alcala-Zermeno, Juan Luis
AU - Gregg, Nicholas M.
AU - Van Gompel, Jamie J.
AU - Stead, Matt
AU - Worrell, Gregory A.
AU - Lundstrom, Brian Nils
N1 - Funding Information:
Research was support by NIH NINDS K23NS112339 (BNL), American Epilepsy Society Research & Training Fellowship for Clinicians (NMG), and NIH NINDS R01NS92882 (GAW).
Funding Information:
Research was support by NIH NINDS K23NS112339 (BNL), American Epilepsy Society Research & Training Fellowship for Clinicians (NMG), and NIH NINDS R01NS92882 (GAW).
Publisher Copyright:
© 2020 The Authors
PY - 2020
Y1 - 2020
N2 - Neuromodulation strategies that target the epileptogenic network are options for treating focal drug-resistant epilepsy. These brain stimulation approaches include responsive neurostimulation and more recently, chronic subthreshold stimulation. Long-term seizure freedom with neuromodulation is uncommon. Seizure control typically requires ongoing froms of electrical stimulation. Here, we present the case of a patient implanted with three cortical electrodes targeting the inferior frontal lobe, insula, and one subcortical electrode targeting the ipsilateral anterior thalamic nucleus. This patient received continuous subthreshold electrical stimulation to the frontal electrodes for 7 months, at which time stimulation was inadvertently stopped. He has now been free of seizures for 42 months. This case suggests the possibility that neuromodulation can alter epileptogenic networks and lead to seizure freedom without ongoing electrical stimulation.
AB - Neuromodulation strategies that target the epileptogenic network are options for treating focal drug-resistant epilepsy. These brain stimulation approaches include responsive neurostimulation and more recently, chronic subthreshold stimulation. Long-term seizure freedom with neuromodulation is uncommon. Seizure control typically requires ongoing froms of electrical stimulation. Here, we present the case of a patient implanted with three cortical electrodes targeting the inferior frontal lobe, insula, and one subcortical electrode targeting the ipsilateral anterior thalamic nucleus. This patient received continuous subthreshold electrical stimulation to the frontal electrodes for 7 months, at which time stimulation was inadvertently stopped. He has now been free of seizures for 42 months. This case suggests the possibility that neuromodulation can alter epileptogenic networks and lead to seizure freedom without ongoing electrical stimulation.
KW - Anterior thalamic nucleus
KW - Chronic subthreshold cortical stimulation
KW - Chronic subthreshold stimulation
KW - Drug-resistant epilepsy
KW - Neuromodulation
KW - Seizure freedom
UR - http://www.scopus.com/inward/record.url?scp=85090727612&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090727612&partnerID=8YFLogxK
U2 - 10.1016/j.ebr.2020.100390
DO - 10.1016/j.ebr.2020.100390
M3 - Article
AN - SCOPUS:85090727612
SN - 2213-3232
VL - 14
JO - Epilepsy and Behavior Reports
JF - Epilepsy and Behavior Reports
M1 - 100390
ER -