Corrigendum to “Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain” [GENE 655 (2018) 1–12] (Gene (2018) 655 (1–12), (S0378111918301963) (10.1016/j.gene.2018.02.048))

Vaskar Das, Ranjan Kc, Xin Li, Disha Varma, Sujun Qiu, Jeffrey S. Kroin, Christopher B. Forsyth, Ali Keshavarzian, Andre J. van Wijnen, Thomas J. Park, Gary S. Stein, Insug O-Sullivan, Thomas P. Burris, Hee Jeong Im

Research output: Contribution to journalComment/debatepeer-review


As the principal investigator and senior author for the above-mentioned publication (Das et al., GENE 2018), it has been brought to my attention that a portion of 2.4. Surgical procedure for OA induction in the Materials and Methods section in this publication contains inaccurate description. Hence, we are respectfully requesting to publish a corrigendum to replace the surgical procedure with proper description and references as below: 2.4. Surgical procedure for OA induction All the surgical operations were performed under a microscope in an aseptic setting. Mice were placed in a supine position and anesthetized with 1.5% isoflurane (Abbott Laboratories, North Chicago, IL, USA) in oxygen via a facemask at a rate of 1 L/min. The toe or tail pinch with toothed forceps were used to assess the depth of anesthesia, and flick responses were interpreted as inadequate anesthesia. After confirming adequate anesthesia, a 1 cm left knee incision was made with a #15 scalpel blade. The knee joint was identified from the tibia and femur; and the medial meniscotibial ligament was identified using anatomic landmarks. To induce partial medial meniscectomy (PMM), which destabilizes the ligaments, a microscalpel at a depth of 0.5 mm was used to remove meniscus at midline (Knights et al., 2012; Kroin; et al., 2016). The skin incision will be then closed with 4–0 vicryl suture. Below two references need to be added: (i) Kroin, J.S., Kc, R., Li, X., Hamilton, J.L., Das, V., van Wijnen, A.J., Dall O.M., Shelly, D.A., Kenworth T., Im, H.J., 2016. Intraarticular Slow-release Triamcinolone Acetate Reduces Allodynia in an Experimental Mouse Knee Osteoarthritis Model. Gene 591, 1–5.(ii) Knights C.B., Gentry C., Bevan S., Partial medial meniscectomy produces osteoarthritis pain-related behavior in female C57BL/6/mice. Pain 2012 153, 281–292.The authors would like to apologise for any inconvenience caused.

Original languageEnglish (US)
Pages (from-to)105
Number of pages1
StatePublished - Jan 5 2019

ASJC Scopus subject areas

  • Genetics


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