Correlation of outcome to neurosurgical lesions: Confirmation of a new method using data after microelectrode-guided pallidotomy

A. A. Obwegeser, R. J. Uitti, J. A. Lucas, R. J. Witte, M. F. Turk, K. Galiano, R. E. Wharen

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The purpose of this study was the development of a new method to correlate functional surgery with outcome measures. Lesions following microelectrode guided globus pallidus internus (GPi) pallidotomy for Parkinson's disease are presented to demonstrate this new method in regard to clinical outcome. A clinical series of 26 patients with extensive neurological and neuropsychological data were studied. Three-month postoperative MRI lesion borders at the AC-PC plane were scaled to a standard size, and the lesions were stored in a virtual array with a cell size of one voxel. The average outcome measure for each voxel is presented graphically. Unified Parkinson's disease rating scale (UPDRS) motor scores improved more with posterolateral and centrally located GPi lesions than with anteromedial lesions. A correlation of lesion location to outcome was also visible for subscales of the UPDRS. The distributions were similar for the left and right sides, as well as for ipsi- and contralateral measurements. In general, verbal fluency decreased after lesioning the dominant hemisphere, and posterolateral lesions caused less impairment. This method enables associative analyses between brain area and outcome down to the size of a few voxels. This may be particularly helpful for planning and validating neurosurgical targets for various disorders.

Original languageEnglish (US)
Pages (from-to)654-662
Number of pages9
JournalBritish Journal of Neurosurgery
Issue number5
StatePublished - Oct 2008


  • Functional neurosurgery
  • Neuropsychology
  • Parkinson's disease

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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