Correlation of Blood Metal Concentrations with Cognitive Scores and Neuroimaging Findings in Patients with Total Joint Arthroplasty

Alican Beba; Stephanie M. Peterson; Peter C. Brennan; Jamie O'Byrne; Mary M. MacHulda; Paul I. Jannetto; Prashanthi Vemuri; David G. Lewallen; Hilal Maradit Kremers; Maria Vassilaki

doi:10.3233/JAD-221182

Correlation of Blood Metal Concentrations with Cognitive Scores and Neuroimaging Findings in Patients with Total Joint Arthroplasty

Alican Beba, Stephanie M. Peterson, Peter C. Brennan, Jamie O'Byrne, Mary M. MacHulda, Paul I. Jannetto, Prashanthi Vemuri, David G. Lewallen, Hilal Maradit Kremers, Maria Vassilaki

Research output: Contribution to journal › Article › peer-review

Abstract

Total joint arthroplasty (TJA) implants are composed of metals, ceramics, and/or polyethylene. Studies suggest that the debris released from metal implants may possess neurotoxic properties with reports of neuropsychiatric symptoms and memory deficits, which could be relevant to Alzheimer's disease and related dementias. This exploratory study examined the cross-sectional correlation of blood metal concentrations with cognitive performance and neuroimaging findings in a convenience sample of 113 TJA patients with history of elevated blood metal concentrations of either titanium, cobalt and/or chromium. Associations with neuroimaging measures were observed but not with cognitive scores. Larger studies with longitudinal follow-up are warranted.

Original language	English (US)
Pages (from-to)	1335-1342
Number of pages	8
Journal	Journal of Alzheimer's Disease
Volume	94
Issue number	4
DOIs	https://doi.org/10.3233/JAD-221182
State	Published - 2023

Keywords

Alzheimer's disease
blood metal concentrations
chromium
cobalt
cognitive function
cognitive scores
magnetic resonance imaging
titanium
total joint arthroplasty

ASJC Scopus subject areas

General Neuroscience
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.3233/JAD-221182

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Beba, A., Peterson, S. M., Brennan, P. C., O'Byrne, J., MacHulda, M. M., Jannetto, P. I., Vemuri, P., Lewallen, D. G., Maradit Kremers, H., & Vassilaki, M. (2023). Correlation of Blood Metal Concentrations with Cognitive Scores and Neuroimaging Findings in Patients with Total Joint Arthroplasty. Journal of Alzheimer's Disease, 94(4), 1335-1342. https://doi.org/10.3233/JAD-221182

Beba, A, Peterson, SM, Brennan, PC, O'Byrne, J, MacHulda, MM, Jannetto, PI, Vemuri, P, Lewallen, DG, Maradit Kremers, H & Vassilaki, M 2023, 'Correlation of Blood Metal Concentrations with Cognitive Scores and Neuroimaging Findings in Patients with Total Joint Arthroplasty', Journal of Alzheimer's Disease, vol. 94, no. 4, pp. 1335-1342. https://doi.org/10.3233/JAD-221182

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abstract = "Total joint arthroplasty (TJA) implants are composed of metals, ceramics, and/or polyethylene. Studies suggest that the debris released from metal implants may possess neurotoxic properties with reports of neuropsychiatric symptoms and memory deficits, which could be relevant to Alzheimer's disease and related dementias. This exploratory study examined the cross-sectional correlation of blood metal concentrations with cognitive performance and neuroimaging findings in a convenience sample of 113 TJA patients with history of elevated blood metal concentrations of either titanium, cobalt and/or chromium. Associations with neuroimaging measures were observed but not with cognitive scores. Larger studies with longitudinal follow-up are warranted.",

keywords = "Alzheimer's disease, blood metal concentrations, chromium, cobalt, cognitive function, cognitive scores, magnetic resonance imaging, titanium, total joint arthroplasty",

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AU - MacHulda, Mary M.

AU - Jannetto, Paul I.

AU - Vemuri, Prashanthi

AU - Lewallen, David G.

AU - Maradit Kremers, Hilal

AU - Vassilaki, Maria

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Correlation of Blood Metal Concentrations with Cognitive Scores and Neuroimaging Findings in Patients with Total Joint Arthroplasty

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Keywords

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