Coronary heart disease is associated with non-amnestic mild cognitive impairment

Rosebud O. Roberts, David S. Knopman, Yonas E. Geda, Ruth H. Cha, Véronique L. Roger, Ronald C. Petersen

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


The progression of amnestic mild cognitive impairment (a-MCI) to Alzheimer's disease and hypothesized progression of non-amnestic mild cognitive impairment (na-MCI) to non-degenerative or vascular dementias suggest etiologic differences. We examined the association between coronary heart disease (CHD) and mild cognitive impairment (MCI) subtypes in a population-based cohort. Participants (n=1969; aged 70-89 years) were evaluated using the Clinical Dementia Rating Scale, a neurological examination, and neuropsychological testing for diagnoses of normal cognition, MCI, or dementia. CHD was defined as a history of myocardial infarction, angina, angiographic coronary stenosis, or coronary revascularization and ascertained by participant interview and from medical records. CHD was significantly associated with na-MCI (OR=1.93; 95% CI=1.22-3.06) but not with a-MCI (OR=0.94; 95% CI=0.69-1.28). In contrast, ApoE e{open}4 allele was significantly associated with a-MCI (OR=1.75; 95% CI=1.28-2.41), but not with na-MCI (OR=1.17; 95% CI=0.69-2.00). The association of CHD with prevalent na-MCI but not with a-MCI suggests that CHD and na-MCI may have similar underlying etiologies.

Original languageEnglish (US)
Pages (from-to)1894-1902
Number of pages9
JournalNeurobiology of aging
Issue number11
StatePublished - Nov 2010


  • Angina
  • Cognitive impairment
  • Coronary artery bypass grafting
  • Coronary heart disease
  • Myocardial infarction
  • Population-based

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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