TY - JOUR
T1 - Coronary flow reserve
T2 - Noninvasive measurement in humans with breath-hold velocity-encoded cine MR imaging
AU - Sakuma, Hajime
AU - Blake, Louis M.
AU - Amidon, Thomas M.
AU - O'Sullivan, Margaret
AU - Szolar, Dieter H.
AU - Furber, Alain P.
AU - Bernstein, Matthew A.
AU - Foo, Thomas K.F.
AU - Higgins, Charles B.
PY - 1996/3
Y1 - 1996/3
N2 - PURPOSE: To measure coronary vasodilator reserve with breath-hold velocity-encoded cine magnetic resonance (MR) imaging. MATERIALS AND METHODS: Eight healthy adult volunteers underwent 1.5-T MR imaging. Velocity-encoded cine images were acquired at seven to 13 temporal phases in 25 seconds, with k-space segmentation and view-sharing reconstruction (±1 m/sec velocity- encoding value) (repetition time msec/echo time msec = 16/9). Flow velocity in the left anterior descending (LAD) artery was measured twice before and twice after administration of dipyridamole (0.56 mg per kilogram of body weight). RESULTS: Peak diastolic coronary flow velocity in the LAD artery was 14.8 cm/sec ± 1.9 (mean ± standard deviation) in the baseline state. It increased significantly (P < .01) to 46.3 cm/sec ± 10.2 after dipyridamole administration, with an average coronary reserve of 3.14 ± 0.59. Interstudy and interobserver reproducibilities for measurement of peak diastolic velocity were, respectively, 9.5% ± 1.6 and 7.0% ± .2.5 in the baseline state and 6.8% ± 2.2 and 3.4% ± 1.5 after dipyridamole administration. CONCLUSION: Breath-hold velocity-encoded cine MR imaging provided reproducible assessment of coronary flow reserve in humans.
AB - PURPOSE: To measure coronary vasodilator reserve with breath-hold velocity-encoded cine magnetic resonance (MR) imaging. MATERIALS AND METHODS: Eight healthy adult volunteers underwent 1.5-T MR imaging. Velocity-encoded cine images were acquired at seven to 13 temporal phases in 25 seconds, with k-space segmentation and view-sharing reconstruction (±1 m/sec velocity- encoding value) (repetition time msec/echo time msec = 16/9). Flow velocity in the left anterior descending (LAD) artery was measured twice before and twice after administration of dipyridamole (0.56 mg per kilogram of body weight). RESULTS: Peak diastolic coronary flow velocity in the LAD artery was 14.8 cm/sec ± 1.9 (mean ± standard deviation) in the baseline state. It increased significantly (P < .01) to 46.3 cm/sec ± 10.2 after dipyridamole administration, with an average coronary reserve of 3.14 ± 0.59. Interstudy and interobserver reproducibilities for measurement of peak diastolic velocity were, respectively, 9.5% ± 1.6 and 7.0% ± .2.5 in the baseline state and 6.8% ± 2.2 and 3.4% ± 1.5 after dipyridamole administration. CONCLUSION: Breath-hold velocity-encoded cine MR imaging provided reproducible assessment of coronary flow reserve in humans.
KW - Coronary vessels, MR
KW - Coronary vessels, flow dynamics
KW - Magnetic resonance (MR), cine study
KW - Magnetic resonance (MR), phase imaging
KW - Magnetic resonance (MR), rapid imaging
KW - Magnetic resonance (MR), vascular studies
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U2 - 10.1148/radiology.198.3.8628864
DO - 10.1148/radiology.198.3.8628864
M3 - Article
C2 - 8628864
AN - SCOPUS:0030024521
SN - 0033-8419
VL - 198
SP - 745
EP - 750
JO - Radiology
JF - Radiology
IS - 3
ER -