Corneal Aberrations and Visual Acuity After Laser In Situ Keratomileusis: Femtosecond Laser Versus Mechanical Microkeratome

Ramón Calvo, Jay W. McLaren, David O. Hodge, William M. Bourne, Sanjay V. Patel

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Purpose: To compare corneal high-order aberrations and visual acuity after laser in situ keratomileusis (LASIK) with the flap created by a femtosecond laser (bladeless) to LASIK with the flap created by a mechanical microkeratome. Design: Prospective, randomized, paired-eye study. Methods: Fellow eyes of 21 patients with myopia or myopic astigmatism were randomized by ocular dominance. Corneal topography and visual acuity were measured before and at 1, 3, 6, 12, and 36 months after LASIK. Wavefront errors from the anterior corneal surface were calculated from the topography data over 4- and 6-mm-diameter pupils and decomposed into Zernike polynomials to the 6th order. Results: There were no differences in corneal total high-order aberrations, spherical aberration, coma, or trefoil between methods of flap creation at any examination over 4- and 6-mm-diameter pupils. Over a 6-mm pupil, total high-order aberrations increased by 1 month after LASIK with both treatments (P ≤ .001) and remained increased through 36 months (P ≤ .001). Uncorrected and best-corrected visual acuity did not differ between methods at any examination and remained stable postoperatively through 3 years; the minimum detectable difference in visual acuity between treatments was ≤0.1 logMAR (≤1 line of vision, α = 0.05/6, β = 0.20, n = 21). Conclusions: The planar configuration of the femtosecond laser flap did not offer any advantage in corneal high-order aberrations or visual acuity through 3 years after LASIK. Corneal high-order aberrations remain stable through 3 years after LASIK.

Original languageEnglish (US)
Pages (from-to)785-793
Number of pages9
JournalAmerican journal of ophthalmology
Issue number5
StatePublished - May 2010

ASJC Scopus subject areas

  • Ophthalmology


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