TY - JOUR
T1 - Cooperative group research efforts in lung cancer
T2 - Focus on early-stage non-small-cell lung cancer
AU - Wakelee, Heather
AU - Langer, Corey
AU - Vokes, Everett
AU - Schiller, Joan
AU - Baas, Paul
AU - Saijo, Nagahiro
AU - Adjei, Alex
AU - Shepherd, Frances
AU - Choy, Hak
AU - Gandara, David R.
PY - 2008/1
Y1 - 2008/1
N2 - Many of the most significant advances in the treatment of lung cancer have come from trials run within the cooperative group system. The leaders of the lung cancer section of each group interact throughout the year, but an annual lung cancer congress in Hawaii provides a forum for extensive discussions of ongoing and planned trials. This article is the first in a series that will focus on the key points of this discussion held at the 8th Annual Lung Cancer Congress in June 2007. Early-stage non-small-cell lung cancer trials are highlighted in this manuscript. Current work in adjuvant therapy is focused on exploring the use of bevacizumab in addition to chemotherapy for resected disease in a large Intergroup study and the use of more "personalized" chemotherapy based on specific genomic or protein expression profiles of individual tumors in smaller exploratory studies. The question of postoperative radiation therapy is being addressed within the cooperative groups. Alternative approaches to surgery, such as lesser resections in smaller tumors and accelerated radiation including stereotactic radiosurgery, are also under investigation within this framework. Ongoing trials within the cooperative groups continue to drive steady improvement in the treatment of lung cancer and offer great promise for the future.
AB - Many of the most significant advances in the treatment of lung cancer have come from trials run within the cooperative group system. The leaders of the lung cancer section of each group interact throughout the year, but an annual lung cancer congress in Hawaii provides a forum for extensive discussions of ongoing and planned trials. This article is the first in a series that will focus on the key points of this discussion held at the 8th Annual Lung Cancer Congress in June 2007. Early-stage non-small-cell lung cancer trials are highlighted in this manuscript. Current work in adjuvant therapy is focused on exploring the use of bevacizumab in addition to chemotherapy for resected disease in a large Intergroup study and the use of more "personalized" chemotherapy based on specific genomic or protein expression profiles of individual tumors in smaller exploratory studies. The question of postoperative radiation therapy is being addressed within the cooperative groups. Alternative approaches to surgery, such as lesser resections in smaller tumors and accelerated radiation including stereotactic radiosurgery, are also under investigation within this framework. Ongoing trials within the cooperative groups continue to drive steady improvement in the treatment of lung cancer and offer great promise for the future.
KW - Adjuvant chemotherapy
KW - Adjuvant radiation therapy
KW - Stereotactic radiosurgery
UR - http://www.scopus.com/inward/record.url?scp=39149120268&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39149120268&partnerID=8YFLogxK
U2 - 10.3816/CLC.2008.n.002
DO - 10.3816/CLC.2008.n.002
M3 - Review article
C2 - 18282352
AN - SCOPUS:39149120268
SN - 1525-7304
VL - 9
SP - 9
EP - 15
JO - Clinical lung cancer
JF - Clinical lung cancer
IS - 1
ER -