Contrasting influences of age and sex on muscle fatigue

David W. Russ, Theodore F. Towse, Danielle M. Wigmore, Ian R. Lanza, Jane A. Kent-Braun

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


PURPOSE: Greater resistance to muscle fatigue has been observed in women versus men and in older versus young individuals. As suggested mechanisms for these differences include task intensity and duty cycle, the purpose of this study was to evaluate fatigue in healthy young and older men and women during maximum-effort isometric contractions with a 70% duty cycle (7 s of contraction, 3 s of rest). We hypothesized that no differences in fatigue would be observed across age or sex, in contrast to studies incorporating lower duty cycles. METHODS: The protocol was carried out on ankle dorsiflexors of older (73 ± 1 yr) and younger (25 ± 1 yr) men and women. Volitional and stimulated force, compound muscle action potential, and muscle contractile responses were collected before, during, and immediately after the fatigue protocol. These measurements allowed for assessment of fatigue as well as central and peripheral activation. RESULTS: At baseline, older subjects had longer force half-relaxation times and less twitch potentiation than younger subjects, consistent with a slower muscle phenotype. During contractions, younger subjects fatigued more than older subjects did, with no differences between men and women. Central activation decreased similarly in all groups with fatigue. There were no fatigue-related differences in peripheral excitation or contractile properties attributable to age or sex. CONCLUSIONS: These data indicate that age-related differences in fatigue are observed even during intermittent MVC with a high duty cycle, and that these differences are independent of central and peripheral activation. Further, it seems that sex-based differences in both fatigue and central activation failure were abolished with this duty cycle. Overall, these results suggest that age- and sex-based differences in fatigue arise from distinct mechanisms.

Original languageEnglish (US)
Pages (from-to)234-241
Number of pages8
JournalMedicine and science in sports and exercise
Issue number2
StatePublished - Feb 2008


  • Central activation
  • Contractile properties
  • Duty cycle
  • EMG
  • Gender

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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