Contrasting effects of IFNβ and IVIG in children with central and peripheral demyelination

I. Pirko; N. L. Kuntz; M. Patterson; B. M. Keegan; B. G. Weinshenker; M. Rodriguez

doi:10.1212/01.WNL.0000064163.94122.EB

Contrasting effects of IFNβ and IVIG in children with central and peripheral demyelination

I. Pirko, N. L. Kuntz, M. Patterson, B. M. Keegan, B. G. Weinshenker, M. Rodriguez

Neurology

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Reported are three children with MS who responded dramatically to interferon-β (IFNβ) therapy. While on immunomodulatory therapy, they developed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) that responded to IV immunoglobulin (IVIG) administration. These cases emphasize two interesting observations: 1) IFNβ treatment did not prevent development of CIDP; 2) CIDP in the context of MS responded to IVIG, even though IVIG had no therapeutic effect on the central demyelinating disease.

Original language	English (US)
Pages (from-to)	1697-1699
Number of pages	3
Journal	Neurology
Volume	60
Issue number	10
DOIs	https://doi.org/10.1212/01.WNL.0000064163.94122.EB
State	Published - May 27 2003

ASJC Scopus subject areas

Clinical Neurology

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abstract = "Reported are three children with MS who responded dramatically to interferon-β (IFNβ) therapy. While on immunomodulatory therapy, they developed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) that responded to IV immunoglobulin (IVIG) administration. These cases emphasize two interesting observations: 1) IFNβ treatment did not prevent development of CIDP; 2) CIDP in the context of MS responded to IVIG, even though IVIG had no therapeutic effect on the central demyelinating disease.",

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AU - Kuntz, N. L.

AU - Patterson, M.

AU - Keegan, B. M.

AU - Weinshenker, B. G.

AU - Rodriguez, M.

PY - 2003/5/27

Y1 - 2003/5/27

N2 - Reported are three children with MS who responded dramatically to interferon-β (IFNβ) therapy. While on immunomodulatory therapy, they developed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) that responded to IV immunoglobulin (IVIG) administration. These cases emphasize two interesting observations: 1) IFNβ treatment did not prevent development of CIDP; 2) CIDP in the context of MS responded to IVIG, even though IVIG had no therapeutic effect on the central demyelinating disease.

AB - Reported are three children with MS who responded dramatically to interferon-β (IFNβ) therapy. While on immunomodulatory therapy, they developed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) that responded to IV immunoglobulin (IVIG) administration. These cases emphasize two interesting observations: 1) IFNβ treatment did not prevent development of CIDP; 2) CIDP in the context of MS responded to IVIG, even though IVIG had no therapeutic effect on the central demyelinating disease.

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Contrasting effects of IFNβ and IVIG in children with central and peripheral demyelination

Abstract

ASJC Scopus subject areas

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