Contemporary Outcomes of Transfemoral Amputation After Total Knee Arthroplasty

Matthew B. Shirley, Michael B. Stuart, Matthew R. Claxton, Paul L. Sousa, Kevin I. Perry, Cory G. Couch, Karen L. Andrews, Matthew T. Houdek

Research output: Contribution to journalArticlepeer-review


Background: Transfemoral amputation (TFA) is a salvage procedure for unreconstructable failed total knee arthroplasty (TKA). Prior studies have reported poor outcomes, patient survival, and prosthetic use. The purpose of this study was to analyze patient outcomes and prosthetic utilization in a contemporary group of patients undergoing TFA in the setting of a TKA. Methods: We reviewed 112 patients undergoing TFA with a prior TKA. Indications for amputation and postoperative functional measures were captured through chart review. Patients were contacted by survey to assess the quality of life. The mean follow-up after TFA was 4 years. Results: Amputations were performed for a chronically infected TKA (n = 87, 78%) and an ischemic limb without signs of an infected TKA (n = 22, 20%). The 10-year survival after TFA was 21%. Of the patients not lost to follow-up, 53 (47%) patients were fitted for a prosthesis. Patients who underwent a TFA after the year 2000 were more likely to be fit for a prosthesis (odds ratio 7.27, P <.01); however, patients were likely to be ambulatory before TFA than after TFA (odds ratio 3.68, P <.01). After TFA, the mean 12-Item Short Form Survey scores for the mental and physical components were 54 ± 13 and 34 ± 7, with no difference in scores between patients fitted for a prosthesis and those who were not (P >.05). Conclusion: Patients undergoing a TFA after TKA due to failure of the TKA are more likely to be fit for a prosthesis; however, they reported no better quality of life and satisfaction compared with patients not fit for a prosthesis. Levels of Evidence: Level III, Therapeutic.

Original languageEnglish (US)
Pages (from-to)1359-1363
Number of pages5
JournalJournal of Arthroplasty
Issue number7
StatePublished - Jul 2022


  • above-knee amputation
  • outcome
  • prosthesis
  • total knee arthroplasty
  • transfemoral amputation

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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