Consensus statement on the diagnosis of multiple system atrophy

S. Gilman, P. A. Low, N. Quinn, A. Albanese, Y. Ben-Shlomo, C. J. Fowler, H. Kaufmann, T. Klockgether, A. E. Lang, P. L. Lantos, I. Litvan, C. J. Mathias, E. Oliver, D. Robertson, I. Schatz, G. K. Wenning

Research output: Contribution to journalArticlepeer-review

921 Scopus citations


We report the results of a consensus conference on the diagnosis of multiple system atrophy (MSA). We describe the clinical features of the disease, which include four domains: autonomic failure/urinary dysfunction, parkinsonism and cerebellar ataxia, and corticospinal dysfunction. We set criteria to define the relative importance of these features. The diagnosis of possible MSA requires one criterion plus two features from separate other domains. The diagnosis of probable MSA requires the criterion for autonomic failure/urinary dysfunction plus poorly levodopa responsive parkinsonism or cerebellar ataxia. The diagnosis of definite MSA requires pathological confirmation.

Original languageEnglish (US)
Pages (from-to)94-98
Number of pages5
JournalJournal of the neurological sciences
Issue number1
StatePublished - Feb 1 1999


  • Autonomic insufficiency
  • Cerebellar ataxia
  • Glial cytoplasmic inclusion
  • Multiple system atrophy
  • Parkinsonism
  • Urinary dysfunction

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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