Concentration of hs-Troponin in small cohort of transgender patients

Stephen Boone, W. Frank Peacock, Alan H.B. Wu, Allan Jaffe, Robert H. Christenson, Frederic M. Ettner, Shahriar Dadkhah

Research output: Contribution to journalArticlepeer-review


Introduction: Sex-differences in high sensitivity troponin (hs-Tn) concentrations are well established. There is, however, limited data to guide interpretation of hs-Tn in transgender patients, particularly those receiving gender-affirming hormone therapy. Our purpose was to evaluate troponin testing in transgender patients. Methods: Transgender adults attending a routine clinic visit provided demographic data, medical history, and venous blood samples. Patients with congestive heart failure or chronic kidney disease were excluded. hs-Tn was measured using the Architect Stat High Sensitivity Troponin-I (Abbott), Access 2 hsTnI (Beckman Coulter), and Elecsys Troponin T Gen 5 STAT (Roche) assays. hs-Tn below the limit of detection (LOD) is reported as the lower limit of detection (LLOD) Results: Of 63 subjects, 76 % were transgender women. We found no significant difference in median hs-Tn concentrations or proportions of hs-Tn > LOD. Conclusion: In this cohort of stable transgender patients without CHF or CKD, we did not observe differences in hs-Tn concentrations between transgender women and transgender men. Meaningful conclusions are limited owing to inadequate sample size and population differences. Further research on hs-troponin concentrations in this underrepresented, vulnerable population is needed.

Original languageEnglish (US)
Pages (from-to)66-69
Number of pages4
JournalClinica Chimica Acta
StatePublished - Jan 15 2023


  • Cardiac biomarkers
  • High-sensitivity troponin
  • Transgender
  • Troponin

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical


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