Computer assessment of depression: Automating the hamilton depression rating scale

Kenneth A. Kobak, James C. Mundt, John H. Greist, David J. Katzelnick, James W. Jefferson

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Current clinical computing systems have evolved over the past three decades and can now be implemented from any touch-tone telephone using interactive voice response (IVR) technology, permitting accessibility 24 hours a day, 7 days a week. Ten years of research and development investigating computer automation of the Hamilton Depression Rating Scale (HDRS), involving 10 separate studies and 1761 subjects, shows strong correspondence with clinician administered assessments. The psychometric properties concerning assessment reliability and validity of clinician- and computer-administered versions of the HDRS are compared and points of divergence between methods drawn from a recently completed clinical trial are discussed. Future challenges facing expanded use of such clinical computing systems in clinical trials of investigational drugs are also discussed.

Original languageEnglish (US)
Pages (from-to)145-156
Number of pages12
JournalDrug Information Journal
Issue number1
StatePublished - Jan 1 2000


  • Clinical assessment
  • Depression
  • Electronic data capture
  • Interactive Voice Response (IVR)

ASJC Scopus subject areas

  • Pharmacology (nursing)
  • Drug guides
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)


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