Composite Hodgkin and non-Hodgkin lymphoma of the mitral and aortic valves

Amber D. Khanna, Harold M. Burkhart, Marosh Manduch, Andrew L. Feldman, David J. Inwards, Heidi M. Connolly

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


A 58-year-old man with a remote history of diffuse large B-cell lymphoma (DLBCL), status post chemotherapy, radiation, and peripheral blood stem cell transplantation, presented with splenic nodular sclerosis classical Hodgkin lymphoma. He was found to have aortic and mitral valve mass lesions. The mitral valve mass showed typical histologic and immunophenotypic features of nodular sclerosis classical Hodgkin lymphoma, whereas the aortic valve mass and aortic mitral curtain tissue showed DLBCL with necrosis. Both tumors were Epstein-Barr virus positive and were clonally related; however, they were not related to his DLBCL from 14 years prior. This is the first case report of a patient with a composite lymphoma affecting two cardiac valves.

Original languageEnglish (US)
Pages (from-to)1113.e5-1113.e7
JournalJournal of the American Society of Echocardiography
Issue number10
StatePublished - Oct 2010


  • Lymphoma
  • Mitral valve
  • Transesophageal echocardiography
  • Tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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