Comparison of six pharmacologic regimens for hypercholesterolemia

Jeffrey M. Hoeg, Martha B. Maher, Kent R. Bailey, H. Bryan Brewer

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Six sequential clinical trials were conducted over 5 years to evaluate the safety and efficacy of different treatment regimens for hypercholesterolemia. Of all the study participants, 11 patients were evaluated in all 6 clinical trials using the following regimens: neomycin, neomycin/niacin, cholestyramine, cholestyramine/neomycin, lovastatin and lovastatin/neomycin. All 6 regimens significantly (p <0.05) reduced both total and low-density lipoprotein cholesterol concentrations by 25 to 42 % from baseline levels. Only neomycin/niacin, cholestyramine and lovastatin significantly increased the high-density lipoprotein (HDL) cholesterol concentration, reducing the total cholesterol/high-density lipoprotein cholesterol ratio to less than 4.7. Thus, all 6 tested regimens were effective in modifying the plasma lipoprotein concentrations in type 11 hyperlipoproteinemia, but neomydn/niacin, cholestyramine and lovastatin had the most favorable Impact. Only lovastatin treatment was free of adverse effects.

Original languageEnglish (US)
Pages (from-to)812-815,816
JournalThe American journal of cardiology
Issue number8
StatePublished - Apr 1 1987

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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