TY - JOUR
T1 - Comparison of disability level between Early and Late Onset Parkinson’s Disease using WHODAS 2
AU - Nascimento, Isaíra Almeida Pereira da Silva
AU - Nobrega, Kátia Cirilo Costa
AU - Souza, Bruno Rafael Antunes
AU - Barone, Isabela Carneiro
AU - Checchio, Giovanna
AU - Ponciano, Vitória Pereira
AU - de Paula, Clara Greif Cerveira
AU - Possani, Arieni Nunes
AU - Penha, Natália Cardoso
AU - Helene, André Frazão
AU - Roque, Antonio Carlos
AU - Savica, Rodolfo
AU - Piemonte, Maria Elisa Pimentel
N1 - Publisher Copyright:
Copyright © 2023 Nascimento, Nobrega, Souza, Barone, Checchio, Ponciano, de Paula, Possani, Penha, Helene, Roque, Savica and Piemonte.
PY - 2023
Y1 - 2023
N2 - Background: Parkinson’s disease (PD) is a degenerative neurological disorder that usually affects people over the age of 60. However, 10%–20% of patients have an early onset of PD (EOPD). Objectives: To compare disability levels according to the World Health Organization Disability Assessment Schedule 2.0 (WHODAS-2) between people with EOPD and those with late-onset PD (LOPD). Methods: We conducted a cross-sectional study with 95 EOPD patients (mean-age 44.51 ± 4.63, H&Y 1.93 ± 0.93) and 255 LOPD patients (mean-age 63.01 ± 7.99, H&Y 2.02 ± 0.95). Demographic information, clinical characteristics, cognitive evaluation by Telephone-Montreal-Cognitive-Assessment (T-MoCA), functionality self-evaluation by WHODAS-2 and the Unified-Parkinson’s-Disease-Rating-Scale (MDS-UPDRS), parts I and II, were documented for each patient by an individual remote interview. Results: Analysis showed a statistically significant difference between EOPD and LOPD in two domains of WHODAS-2 only: cognition (Z-adjusted = 2.60; p-value adjusted <0.009) and activities of daily living related to work/school (Z-adjusted = 2.34; p-value adjusted <0.01). T-MoCA scores confirmed more impaired cognition capacity in LOPD (Z-adjusted = 2.42; p-value adjusted <0.01). The two groups had no significant differences in levodopa daily dosage, Hoehn and Yahr (H&Y) stages, disease time duration, and MDS-UPDRS I and II scores. Conclusion: People living with EOPD face similar disability levels as those with LOPD, except for cognition, where LOPD patients exhibited higher levels of disability than EOPD and for work activities where the EOPD exhibited higher levels of disability than LODP. These results highlight the challenges faced by people with EOPD in interacting with society and living with the disease for a longer time. The WHODAS-2 can be a useful tool to assess disability and tailor interventions for people with PD of different age groups.
AB - Background: Parkinson’s disease (PD) is a degenerative neurological disorder that usually affects people over the age of 60. However, 10%–20% of patients have an early onset of PD (EOPD). Objectives: To compare disability levels according to the World Health Organization Disability Assessment Schedule 2.0 (WHODAS-2) between people with EOPD and those with late-onset PD (LOPD). Methods: We conducted a cross-sectional study with 95 EOPD patients (mean-age 44.51 ± 4.63, H&Y 1.93 ± 0.93) and 255 LOPD patients (mean-age 63.01 ± 7.99, H&Y 2.02 ± 0.95). Demographic information, clinical characteristics, cognitive evaluation by Telephone-Montreal-Cognitive-Assessment (T-MoCA), functionality self-evaluation by WHODAS-2 and the Unified-Parkinson’s-Disease-Rating-Scale (MDS-UPDRS), parts I and II, were documented for each patient by an individual remote interview. Results: Analysis showed a statistically significant difference between EOPD and LOPD in two domains of WHODAS-2 only: cognition (Z-adjusted = 2.60; p-value adjusted <0.009) and activities of daily living related to work/school (Z-adjusted = 2.34; p-value adjusted <0.01). T-MoCA scores confirmed more impaired cognition capacity in LOPD (Z-adjusted = 2.42; p-value adjusted <0.01). The two groups had no significant differences in levodopa daily dosage, Hoehn and Yahr (H&Y) stages, disease time duration, and MDS-UPDRS I and II scores. Conclusion: People living with EOPD face similar disability levels as those with LOPD, except for cognition, where LOPD patients exhibited higher levels of disability than EOPD and for work activities where the EOPD exhibited higher levels of disability than LODP. These results highlight the challenges faced by people with EOPD in interacting with society and living with the disease for a longer time. The WHODAS-2 can be a useful tool to assess disability and tailor interventions for people with PD of different age groups.
KW - cognition
KW - disability
KW - early onset
KW - Parkinson’s disease
KW - WHODAS-2
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UR - http://www.scopus.com/inward/citedby.url?scp=85178202093&partnerID=8YFLogxK
U2 - 10.3389/fneur.2023.1281537
DO - 10.3389/fneur.2023.1281537
M3 - Article
AN - SCOPUS:85178202093
SN - 1664-2295
VL - 14
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 1281537
ER -