Comparative study of therapy-related and de novo adult b-cell acute lymphoblastic leukaemia

Zaid H. Abdel Rahman, Ricardo D. Parrondo, Michael G. Heckman, Mikolaj Wieczorek, Kevin C. Miller, Hassan Alkhateeb, Lisa Z. Sproat, Hemant Murthy, William J. Hogan, Mohamed A. Kharfan-Dabaja, Jess F. Peterson, Linda B. Baughn, Nicole Hoppman, Mark R. Litzow, Rhett P. Ketterling, Patricia T. Greipp, James M. Foran

Research output: Contribution to journalArticlepeer-review


We report a comparative analysis of patients with therapy-related acute lymphoblastic leukaemia (tr-ALL) vs de novo ALL. We identified 331 patients with B-ALL; 69 (21%) were classified as tr-ALL. The most common prior malignancies were breast (23·2%) and plasma cell disorders (20·3%). Patients with tr-ALL were older (median 63·2 vs. 46·2 years, P < 0.001), more often female (66·7% vs. 43·5%, P < 0·001), and more likely to have hypodiploid cytogenetics (18·8% vs. 5·0%, P < 0·001). In multivariable analysis, patients with tr-ALL were less likely to achieve complete remission [odds ratio (OR) = 0·16, P < 0·001] and more likely to be minimal residual disease-positive (OR = 4·86, P = 0·01) but had similar OS after diagnosis and allo-haematopoietic cell transplantation.

Original languageEnglish (US)
Pages (from-to)963-968
Number of pages6
JournalBritish journal of haematology
Issue number4
StatePublished - Feb 2022


  • ALL
  • FISH
  • leukemia
  • therapy-related

ASJC Scopus subject areas

  • Hematology


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