@article{c752b51652754e2e8230f6f5d01fd84a,
title = "Comparative study of therapy-related and de novo adult b-cell acute lymphoblastic leukaemia",
abstract = "We report a comparative analysis of patients with therapy-related acute lymphoblastic leukaemia (tr-ALL) vs de novo ALL. We identified 331 patients with B-ALL; 69 (21%) were classified as tr-ALL. The most common prior malignancies were breast (23·2%) and plasma cell disorders (20·3%). Patients with tr-ALL were older (median 63·2 vs. 46·2 years, P < 0.001), more often female (66·7% vs. 43·5%, P < 0·001), and more likely to have hypodiploid cytogenetics (18·8% vs. 5·0%, P < 0·001). In multivariable analysis, patients with tr-ALL were less likely to achieve complete remission [odds ratio (OR) = 0·16, P < 0·001] and more likely to be minimal residual disease-positive (OR = 4·86, P = 0·01) but had similar OS after diagnosis and allo-haematopoietic cell transplantation.",
keywords = "ALL, FISH, leukemia, therapy-related",
author = "{Abdel Rahman}, {Zaid H.} and Parrondo, {Ricardo D.} and Heckman, {Michael G.} and Mikolaj Wieczorek and Miller, {Kevin C.} and Hassan Alkhateeb and Sproat, {Lisa Z.} and Hemant Murthy and Hogan, {William J.} and Kharfan-Dabaja, {Mohamed A.} and Peterson, {Jess F.} and Baughn, {Linda B.} and Nicole Hoppman and Litzow, {Mark R.} and Ketterling, {Rhett P.} and Greipp, {Patricia T.} and Foran, {James M.}",
note = "Funding Information: This publication is supported in part by a grant from the Conquer Cancer Foundation (CCF) of the American Society of Clinical Oncology (ASCO), and a Young Investigator Award (YIA) funded by the Florida Society of Clinical Oncology and awarded to Dr. Zaid H. Abdel Rahman. Some of the data in this publication were produced in the Mayo Clinic Cytogenetics Core Laboratory which is supported, in part, by a Mayo Clinic Comprehensive Cancer Center Grant, funded by National Cancer Institute (P30CA15083). Publisher Copyright: {\textcopyright} 2021 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.",
year = "2022",
month = feb,
doi = "10.1111/bjh.17906",
language = "English (US)",
volume = "196",
pages = "963--968",
journal = "British journal of haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "4",
}