Comparative study of therapy-related and de novo adult b-cell acute lymphoblastic leukaemia

Zaid H. Abdel Rahman; Ricardo D. Parrondo; Michael G. Heckman; Mikolaj Wieczorek; Kevin C. Miller; Hassan Alkhateeb; Lisa Z. Sproat; Hemant Murthy; William J. Hogan; Mohamed A. Kharfan-Dabaja; Jess F. Peterson; Linda B. Baughn; Nicole Hoppman; Mark R. Litzow; Rhett P. Ketterling; Patricia T. Greipp; James M. Foran

doi:10.1111/bjh.17906

Comparative study of therapy-related and de novo adult b-cell acute lymphoblastic leukaemia

Zaid H. Abdel Rahman, Ricardo D. Parrondo, Michael G. Heckman, Mikolaj Wieczorek, Kevin C. Miller, Hassan Alkhateeb, Lisa Z. Sproat, Hemant Murthy, William J. Hogan, Mohamed A. Kharfan-Dabaja, Jess F. Peterson, Linda B. Baughn, Nicole Hoppman, Mark R. Litzow, Rhett P. Ketterling, Patricia T. Greipp, James M. Foran

Research output: Contribution to journal › Article › peer-review

Abstract

We report a comparative analysis of patients with therapy-related acute lymphoblastic leukaemia (tr-ALL) vs de novo ALL. We identified 331 patients with B-ALL; 69 (21%) were classified as tr-ALL. The most common prior malignancies were breast (23·2%) and plasma cell disorders (20·3%). Patients with tr-ALL were older (median 63·2 vs. 46·2 years, P < 0.001), more often female (66·7% vs. 43·5%, P < 0·001), and more likely to have hypodiploid cytogenetics (18·8% vs. 5·0%, P < 0·001). In multivariable analysis, patients with tr-ALL were less likely to achieve complete remission [odds ratio (OR) = 0·16, P < 0·001] and more likely to be minimal residual disease-positive (OR = 4·86, P = 0·01) but had similar OS after diagnosis and allo-haematopoietic cell transplantation.

Original language	English (US)
Pages (from-to)	963-968
Number of pages	6
Journal	British journal of haematology
Volume	196
Issue number	4
DOIs	https://doi.org/10.1111/bjh.17906
State	Published - Feb 2022

Keywords

ALL
FISH
leukemia
therapy-related

ASJC Scopus subject areas

Hematology

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10.1111/bjh.17906

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Abdel Rahman, Z. H., Parrondo, R. D., Heckman, M. G., Wieczorek, M., Miller, K. C., Alkhateeb, H., Sproat, L. Z., Murthy, H., Hogan, W. J., Kharfan-Dabaja, M. A., Peterson, J. F., Baughn, L. B., Hoppman, N., Litzow, M. R., Ketterling, R. P., Greipp, P. T., & Foran, J. M. (2022). Comparative study of therapy-related and de novo adult b-cell acute lymphoblastic leukaemia. British journal of haematology, 196(4), 963-968. https://doi.org/10.1111/bjh.17906

Abdel Rahman, ZH, Parrondo, RD, Heckman, MG, Wieczorek, M, Miller, KC, Alkhateeb, H, Sproat, LZ, Murthy, H, Hogan, WJ, Kharfan-Dabaja, MA, Peterson, JF, Baughn, LB, Hoppman, N, Litzow, MR, Ketterling, RP, Greipp, PT & Foran, JM 2022, 'Comparative study of therapy-related and de novo adult b-cell acute lymphoblastic leukaemia', British journal of haematology, vol. 196, no. 4, pp. 963-968. https://doi.org/10.1111/bjh.17906

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title = "Comparative study of therapy-related and de novo adult b-cell acute lymphoblastic leukaemia",

abstract = "We report a comparative analysis of patients with therapy-related acute lymphoblastic leukaemia (tr-ALL) vs de novo ALL. We identified 331 patients with B-ALL; 69 (21%) were classified as tr-ALL. The most common prior malignancies were breast (23·2%) and plasma cell disorders (20·3%). Patients with tr-ALL were older (median 63·2 vs. 46·2 years, P < 0.001), more often female (66·7% vs. 43·5%, P < 0·001), and more likely to have hypodiploid cytogenetics (18·8% vs. 5·0%, P < 0·001). In multivariable analysis, patients with tr-ALL were less likely to achieve complete remission [odds ratio (OR) = 0·16, P < 0·001] and more likely to be minimal residual disease-positive (OR = 4·86, P = 0·01) but had similar OS after diagnosis and allo-haematopoietic cell transplantation.",

keywords = "ALL, FISH, leukemia, therapy-related",

author = "{Abdel Rahman}, {Zaid H.} and Parrondo, {Ricardo D.} and Heckman, {Michael G.} and Mikolaj Wieczorek and Miller, {Kevin C.} and Hassan Alkhateeb and Sproat, {Lisa Z.} and Hemant Murthy and Hogan, {William J.} and Kharfan-Dabaja, {Mohamed A.} and Peterson, {Jess F.} and Baughn, {Linda B.} and Nicole Hoppman and Litzow, {Mark R.} and Ketterling, {Rhett P.} and Greipp, {Patricia T.} and Foran, {James M.}",

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year = "2022",

month = feb,

doi = "10.1111/bjh.17906",

language = "English (US)",

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T1 - Comparative study of therapy-related and de novo adult b-cell acute lymphoblastic leukaemia

AU - Abdel Rahman, Zaid H.

AU - Parrondo, Ricardo D.

AU - Heckman, Michael G.

AU - Wieczorek, Mikolaj

AU - Miller, Kevin C.

AU - Alkhateeb, Hassan

AU - Sproat, Lisa Z.

AU - Murthy, Hemant

AU - Hogan, William J.

AU - Kharfan-Dabaja, Mohamed A.

AU - Peterson, Jess F.

AU - Baughn, Linda B.

AU - Hoppman, Nicole

AU - Litzow, Mark R.

AU - Ketterling, Rhett P.

AU - Greipp, Patricia T.

AU - Foran, James M.

PY - 2022/2

Y1 - 2022/2

N2 - We report a comparative analysis of patients with therapy-related acute lymphoblastic leukaemia (tr-ALL) vs de novo ALL. We identified 331 patients with B-ALL; 69 (21%) were classified as tr-ALL. The most common prior malignancies were breast (23·2%) and plasma cell disorders (20·3%). Patients with tr-ALL were older (median 63·2 vs. 46·2 years, P < 0.001), more often female (66·7% vs. 43·5%, P < 0·001), and more likely to have hypodiploid cytogenetics (18·8% vs. 5·0%, P < 0·001). In multivariable analysis, patients with tr-ALL were less likely to achieve complete remission [odds ratio (OR) = 0·16, P < 0·001] and more likely to be minimal residual disease-positive (OR = 4·86, P = 0·01) but had similar OS after diagnosis and allo-haematopoietic cell transplantation.

AB - We report a comparative analysis of patients with therapy-related acute lymphoblastic leukaemia (tr-ALL) vs de novo ALL. We identified 331 patients with B-ALL; 69 (21%) were classified as tr-ALL. The most common prior malignancies were breast (23·2%) and plasma cell disorders (20·3%). Patients with tr-ALL were older (median 63·2 vs. 46·2 years, P < 0.001), more often female (66·7% vs. 43·5%, P < 0·001), and more likely to have hypodiploid cytogenetics (18·8% vs. 5·0%, P < 0·001). In multivariable analysis, patients with tr-ALL were less likely to achieve complete remission [odds ratio (OR) = 0·16, P < 0·001] and more likely to be minimal residual disease-positive (OR = 4·86, P = 0·01) but had similar OS after diagnosis and allo-haematopoietic cell transplantation.

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KW - FISH

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KW - therapy-related

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Comparative study of therapy-related and de novo adult b-cell acute lymphoblastic leukaemia

Abstract

Keywords

ASJC Scopus subject areas

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