Companion animals: Translational scientist's new best friends

Amir Kol, Boaz Arzi, Kyriacos A. Athanasiou, Diana L. Farmer, Jan A. Nolta, Robert B. Rebhun, Xinbin Chen, Leigh G. Griffiths, Frank J.M. Verstraete, Christopher J. Murphy, Dori L. Borjesson

Research output: Contribution to journalArticlepeer-review

87 Scopus citations


Knowledge and resources derived from veterinary medicine represent an underused resource that could serve as a bridge between data obtained from diseases models in laboratory animals and human clinical trials. Naturally occurring disease in companion animals that display the defining attributes of similar, if not identical, diseases in humans hold promise for providing predictive proof of concept in the evaluation of new therapeutics and devices. Here we outline comparative aspects of naturally occurring diseases in companion animals and discuss their current uses in translational medicine, benefits, and shortcomings. Last, we envision how these natural models of disease might ultimately decrease the failure rate in human clinical trials and accelerate the delivery of effective treatments to the human clinical market.

Original languageEnglish (US)
Article number308ps21
JournalScience translational medicine
Issue number308
StatePublished - Oct 7 2015

ASJC Scopus subject areas

  • General Medicine


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