Colorectal cancer in the setting of pregnancy and familial risk

N. Jewel Samadder, Ken Robert Smith, Jathine Wong, Randall W. Burt, Karen Curtin

Research output: Contribution to journalArticlepeer-review


Background and aims: Women are at risk of colorectal cancer (CRC) during pregnancy but this fact is underappreciated. We performed a population-based study to evaluate the rate, predictors, and familial risk for pregnancy associated CRC in Utah. Methods: All newly diagnosed cases of CRC between 1973 and 2014 were obtained from the Utah Cancer Registry and linked to pedigrees from the Utah Population Database. Results: Of the 12,886 females diagnosed with CRC, 73 were diagnosed with CRC (0.57%) during the period of obstetric delivery/childbirth. Pregnancy associated CRC was diagnosed at a mean age of 31.9 years, and cancers were less frequently located in the proximal colon compared with women with non-pregnancy associated CRC. First-degree relatives of cases with pregnancy associated CRC had a nearly threefold higher risk of CRC (OR, 2.76; 95% CI, 1.26–6.01) compared with relatives of CRC-free individuals. Conclusions: Of women diagnosed with CRC, less than 1% were diagnosed during or soon after obstetric delivery/childbirth. Relatives of these patients have a nearly threefold greater risk of CRC than those without a family history of CRC. These results provide physicians with data to guide the care of patients and their relatives with pregnancy associated CRC.

Original languageEnglish (US)
Pages (from-to)1559-1566
Number of pages8
JournalInternational Journal of Colorectal Disease
Issue number8
StatePublished - Aug 1 2020


  • Colon cancer
  • Heritable
  • Pregnancy

ASJC Scopus subject areas

  • Gastroenterology


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