Collagenous Gastritis: Characteristics and Response to Topical Budesonide

Rok Seon Choung, Ayush Sharma, Victor G. Chedid, Imad Absah, Zongming Eric Chen, Joseph A. Murray

Research output: Contribution to journalArticlepeer-review


Background and aims: Collagenous gastritis (CG) is a rare disorder characterized by subepithelial collagen deposition in the stomach. Standard medications have been only moderately successful in treating CG. We report results of a large, retrospective, open-label noncontrolled study of topical budesonide for CG, with an aim of establishing an alternative therapy for the disease. Methods: We identified patients treated for CG at Mayo Clinic (2000–2017) with topically targeted budesonide (TTB) in 2 formulations: open-capsule budesonide or compounded immediate-release budesonide capsule. Demographic, clinical, biochemical, and histologic variables were assessed for all patients before and after treatment. Results: We identified 64 patients with CG (50 adults, 14 children). Most were female (68%), mean age was 41 ± 22.8 years, and body mass index was 23.1 ± 5.9 kg/m2. In most pediatric patients, CG presented with abdominal pain and anemia; in adults, CG presented more often with weight loss (P < .001). Collagenous sprue or colitis were more common in patients >50 years of age (83%) vs those 19–50 years of age (27%) or <19 years of age (50%) (P < .001). Of the patients treated with TTB, 89% had a clinical response to TTB (42% complete, 46% partial), and 88% had a histologic response (53% complete, 33% partial). Conclusions: Adults and children with CG have a wide variety of symptoms, and notably, TTB therapy produced clinical and histologic improvement after other therapy had failed.

Original languageEnglish (US)
Pages (from-to)1977-1985.e1
JournalClinical Gastroenterology and Hepatology
Issue number9
StatePublished - Sep 2022


  • Budesonide
  • Collagenous Gastritis
  • Corticosteroids

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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