Cognitive profile of LRRK2-related Parkinson's disease

Sindhu Srivatsal, Brenna Cholerton, James B. Leverenz, Zbigniew K. Wszolek, Ryan J. Uitti, Dennis W. Dickson, Daniel Weintraub, John Q. Trojanowski, Vivianna M. Van Deerlin, Joseph F. Quinn, Kathryn A. Chung, Amie L. Peterson, Stewart A. Factor, Cathy Wood-Siverio, Jennifer G. Goldman, Glenn T. Stebbins, Bryan Bernard, Beate Ritz, Rebecca Rausch, Alberto J. EspayFredy J. Revilla, Johnna Devoto, Liana S. Rosenthal, Ted M. Dawson, Marilyn S. Albert, Ignacio F. Mata, Shu Ching Hu, Kathleen S. Montine, Catherine Johnson, Thomas J. Montine, Karen L. Edwards, Jing Zhang, Cyrus P. Zabetian

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Background: Increasing evidence suggests that genetic factors play a role in the variability associated with cognitive performance in Parkinson's disease (PD). Mutations in the LRRK2 gene are the most common cause of monogenic PD; however, the cognitive profile of LRRK2-related PD is not well-characterized. Methods: A cohort of 1,447 PD patients enrolled in the PD Cognitive Genetics Consortium was screened for LRRK2 mutations and completed detailed cognitive testing. Associations between mutation carrier status and cognitive test scores were assessed using linear regression models. Results: LRRK2 mutation carriers (n=29) demonstrated better performance on the Mini Mental State Examination (P=0.03) and the Letter-Number Sequencing Test (P=0.005). A smaller proportion of LRRK2 carriers were demented (P=0.03). Conclusions: Our cross-sectional study demonstrates better performance on certain cognitive tests, as well as lower rates of dementia in LRRK2-related PD. Future longitudinal studies are needed to determine whether LRRK2 mutation carriers exhibit slower cognitive decline.

Original languageEnglish (US)
Pages (from-to)728-733
Number of pages6
JournalMovement Disorders
Issue number5
StatePublished - Apr 15 2015


  • Cognition
  • LRRK2
  • Neuropsychological tests
  • Parkinson's disease
  • Working memory

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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